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Döbrönte, Z. et al.

Measurement of gastric mucosal blood flow in dogs by the 99mTc-4-methylaminophenazone clearance technique.

In anesthetized dogs, correlation was found between the 99mTc-4-methylaminophenazone and aminopyrine clearance measured in the same animal after administration of the gastric secretory stimulants vasopressin or glucagon. Similar correlation was observed between the 99mTc-4-methylaminophenazone and [14C]aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that 99mTc-4-methylaminophenazone is suitable to study circulatory changes in human gastric mucosa. Advantages of this compound include a much lower dose of radiation absorbed by the patient and his surroundings, a simplified measurement technique, and considerably reduced expenses.[1]

References

Measurement of gastric mucosal blood flow in dogs by the 99mTc-4-methylaminophenazone clearance technique. Döbrönte, Z., Láng, J., Sági, I., Varró, V. Gastroenterology (1982) [Pubmed]

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