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MeSH Review

Gastric Mucosa

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Disease relevance of Gastric Mucosa


Psychiatry related information on Gastric Mucosa


High impact information on Gastric Mucosa

  • This is amply illustrated within the gastric glands that do not secrete mucus and HCO3- yet are exposed to undiluted pepsin and an isotonic solution of HCl [9].
  • Omeprazole blocks the action of H+,K+-ATPase in the gastric mucosa and thus inhibits the secretion of hydrochloric acid [10].
  • That eating and vagal stimulation elicit the release of histamine from gastric mucosa, together with the fact that drinking elicited by eating or exogenous histamine depends on an intact abdominal vagus, suggests a role for endogenous histamine as a component of food-related drinking in the rat [11].
  • Such a sequence is also found adjacent to the phosphotyrosine of middle T antigen, and in the homologous region of the hormone gastrin, adjacent to a tyrosine which is sulphated in approximately half the gastrin isolated from gastric mucosa [12].
  • Recently, we showed that mice infected with reovirus developed a polyendocrine disease with autoantibodies to the pancreas, anterior pituitary, thymus and gastric mucosa [13].

Chemical compound and disease context of Gastric Mucosa


Biological context of Gastric Mucosa


Anatomical context of Gastric Mucosa

  • The present results suggested that the appearance of pyloric glands with a low Pg 1 content in normal-looking mucosa might be an immunohistochemically detectable preneoplastic change preceding morphologically detectable preneoplastic changes in stomach carcinogenesis [24].
  • PACAP effects on ECL cells were analyzed by video imaging of [Ca(2+)](i) and histamine release; its effects on gastric glands were examined by confocal microscopy of [Ca(2+)](i) in ECL and parietal cells [25].
  • Gastric surface mucous cells originate from progenitor cells at the isthmus of the gastric gland, from where the cells migrate to the luminal surface [26].
  • From the results of paradoxical Con A staining and Pg 1 immunostaining, the cells in lesions were classified into gastric types (surface mucous cell type and pyloric gland cell type) and intestinal types (intestinal-absorptive cell type and goblet cell type) [24].
  • RESULTS : LL-37/hCAP18 messenger RNA and protein were expressed in a distinct distribution by surface epithelial cells as well as chief and parietal cells in the fundic glands of normal gastric mucosa [27].

Associations of Gastric Mucosa with chemical compounds

  • Role of PGE2 in anion exchange in gastric mucosa [28].
  • Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa [29].
  • Peppers, capsaicin, and the gastric mucosa [30].
  • These results demonstrate that the peptido-leukotrienes derived from eicosapentaenoic acid (LTC5 and LTD5) are on the order of five times less potent than the leukotrienes derived from arachidonic acid (LTC4 and LTD4), in terms of increasing the susceptibility of the gastric mucosa to damage and reducing gastric blood flow [31].
  • Isolated human gastric glands from surgical specimens were preincubated in an oxygenated medium with placebo or 16,16 dimethyl prostaglandin E2 (dmPGE2) and incubated at 37 degrees C in either medium alone, medium containing 4.43 mM indomethacin or medium containing 8% ethanol [32].

Gene context of Gastric Mucosa

  • CONCLUSIONS: Expression of both gastric-foveolar and pyloric-gland mucin in PanINs is an early event, whereas sialyl Tn expression is a late event in the recently defined progression model of pancreatic carcinogenesis [33].
  • Neither pS2 mRNA nor pS2 peptide were shown within the deep portions of the pyloric glands [34].
  • Evolutionary conservation in vertebrates as well as abundant expression of CA IX protein in normal human gastric mucosa, but not in derived tumors, indicate its physiological importance [35].
  • METHODS: Cdx2 expression was directed to the gastric mucosa in transgenic mice using cis-regulatory elements of Foxa3 (Hnf3gamma) [36].
  • METHODS: We studied EGF-R levels, EGF-R phosphorylation levels, and ERK1 and ERK2 activity in normal and ulcerated rat gastric mucosa [37].

Analytical, diagnostic and therapeutic context of Gastric Mucosa


  1. Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: observation by a method in which leucine aminopeptidase activity is used. Nakahara, K. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Sequential histologic changes during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI and resistant BUF rats. Ohgaki, H., Kusama, K., Hasegawa, H., Sato, S., Takayama, S., Sugimura, T. J. Natl. Cancer Inst. (1986) [Pubmed]
  3. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Yamaoka, Y., Kita, M., Kodama, T., Sawai, N., Imanishi, J. Gastroenterology (1996) [Pubmed]
  4. Krebs cycle, pentose phosphate pathway, and glycolysis in the uninvolved gastric mucosa of peptic ulcer and gastric cancer patients. Orwell, R.L., Piper, D.W. Gastroenterology (1977) [Pubmed]
  5. Role of endogenous gastric prostanoids in the pathogenesis and therapy of duodenal ulcer. Rachmilewitz, D., Ligumsky, M., Fich, A., Goldin, E., Eliakim, A., Karmeli, F. Gastroenterology (1986) [Pubmed]
  6. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Tanaka, S., Akiba, Y., Kaunitz, J.D. Gut (1998) [Pubmed]
  7. Effects of dopamine on gastric mucosal lesions induced by ethanol in rats. Possible involvement of antigastric motor activity mediated with alpha 2-adrenoceptors. Takeuchi, K., Nishiwaki, H., Okabe, S. Dig. Dis. Sci. (1988) [Pubmed]
  8. Cyanocobalamin absorption abnormality in alcoholics is improved by oral supplementation with a fermented papaya-derived antioxidant. Marotta, F., Tajiri, H., Barreto, R., Brasca, P., Idéo, G.M., Mondazzi, L., Safran, P., Bobadilla, J., Idéo, G. Hepatogastroenterology (2000) [Pubmed]
  9. Gastroduodenal mucosal protection. Allen, A., Flemström, G., Garner, A., Kivilaakso, E. Physiol. Rev. (1993) [Pubmed]
  10. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. Walan, A., Bader, J.P., Classen, M., Lamers, C.B., Piper, D.W., Rutgersson, K., Eriksson, S. N. Engl. J. Med. (1989) [Pubmed]
  11. Histamine plays a part in induction of drinking by food intake. Kraly, F.S. Nature (1983) [Pubmed]
  12. Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase. Baldwin, G.S., Knesel, J., Monckton, J.M. Nature (1983) [Pubmed]
  13. Multiple organ-reactive monoclonal autoantibodies. Haspel, M.V., Onodera, T., Prabhakar, B.S., McClintock, P.R., Essani, K., Ray, U.R., Yagihashi, S., Notkins, A.L. Nature (1983) [Pubmed]
  14. Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. Leung, F.W., Robert, A., Guth, P.H. Gastroenterology (1985) [Pubmed]
  15. Functional impairment of rat enterochromaffin-like cells by interleukin 1 beta. Prinz, C., Neumayer, N., Mahr, S., Classen, M., Schepp, W. Gastroenterology (1997) [Pubmed]
  16. Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa. Klinkenberg-Knol, E.C., Nelis, F., Dent, J., Snel, P., Mitchell, B., Prichard, P., Lloyd, D., Havu, N., Frame, M.H., Romàn, J., Walan, A. Gastroenterology (2000) [Pubmed]
  17. Vagal stimulation rapidly increases leptin secretion in human stomach. Sobhani, I., Buyse, M., Goïot, H., Weber, N., Laigneau, J.P., Henin, D., Soul, J.C., Bado, A. Gastroenterology (2002) [Pubmed]
  18. Gastric ammonia has a potent ulcerogenic action on the rat stomach. Murakami, M., Saita, H., Teramura, S., Dekigai, H., Asagoe, K., Kusaka, S., Kita, T. Gastroenterology (1993) [Pubmed]
  19. Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa. Whittle, B.J., Kauffman, G.L., Moncada, S. Nature (1981) [Pubmed]
  20. Acute effects of N-methyl-N'-nitro-N-nitrosoguanidine on canine gastric mucosa. Kuo, Y.J., Chou, A.C., Shanbour, L.L. J. Natl. Cancer Inst. (1977) [Pubmed]
  21. Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa. Schmassmann, A., Reubi, J.C. J. Clin. Invest. (2000) [Pubmed]
  22. Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. Kobayashi, T., Tonai, S., Ishihara, Y., Koga, R., Okabe, S., Watanabe, T. J. Clin. Invest. (2000) [Pubmed]
  23. Prostaglandin cytoprotection of gastric mucosa. Chaudhury, T.K., Jacobson, E.D. Gastroenterology (1978) [Pubmed]
  24. Immunohistochemical demonstration of pyloric gland-type cells with low-pepsinogen isozyme 1 in preneoplastic and neoplastic tissues of rat stomachs treated with N-methyl-N'-nitro-N-nitrosoguanidine. Tatematsu, M., Furihata, C., Katsuyama, T., Mera, Y., Inoue, T., Matsushima, T., Ito, N. J. Natl. Cancer Inst. (1987) [Pubmed]
  25. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. Zeng, N., Athmann, C., Kang, T., Lyu, R.M., Walsh, J.H., Ohning, G.V., Sachs, G., Pisegna, J.R. J. Clin. Invest. (1999) [Pubmed]
  26. Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cells. Konda, Y., Yokota, H., Kayo, T., Horiuchi, T., Sugiyama, N., Tanaka, S., Takata, K., Takeuchi, T. J. Clin. Invest. (1997) [Pubmed]
  27. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Hase, K., Murakami, M., Iimura, M., Cole, S.P., Horibe, Y., Ohtake, T., Obonyo, M., Gallo, R.L., Eckmann, L., Kagnoff, M.F. Gastroenterology (2003) [Pubmed]
  28. Role of PGE2 in anion exchange in gastric mucosa. Durbin, R.P. Nature (1980) [Pubmed]
  29. Sulfhydryl compounds may mediate gastric cytoprotection. Szabo, S., Trier, J.S., Frankel, P.W. Science (1981) [Pubmed]
  30. Peppers, capsaicin, and the gastric mucosa. Holzer, P. JAMA (1989) [Pubmed]
  31. Comparison of the damage-promoting effects of leukotrienes derived from eicosapentaenoic acid and arachidonic acid on the rat stomach. Wallace, J.L., McKnight, G.W. J. Exp. Med. (1990) [Pubmed]
  32. Prostaglandin protection of human isolated gastric glands against indomethacin and ethanol injury. Evidence for direct cellular action of prostaglandin. Tarnawski, A., Brzozowski, T., Sarfeh, I.J., Krause, W.J., Ulich, T.R., Gergely, H., Hollander, D. J. Clin. Invest. (1988) [Pubmed]
  33. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Kim, G.E., Bae, H.I., Park, H.U., Kuan, S.F., Crawley, S.C., Ho, J.J., Kim, Y.S. Gastroenterology (2002) [Pubmed]
  34. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Hanby, A.M., Poulsom, R., Singh, S., Elia, G., Jeffery, R.E., Wright, N.A. Gastroenterology (1993) [Pubmed]
  35. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Pastoreková, S., Parkkila, S., Parkkila, A.K., Opavský, R., Zelník, V., Saarnio, J., Pastorek, J. Gastroenterology (1997) [Pubmed]
  36. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Silberg, D.G., Sullivan, J., Kang, E., Swain, G.P., Moffett, J., Sund, N.J., Sackett, S.D., Kaestner, K.H. Gastroenterology (2002) [Pubmed]
  37. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Pai, R., Ohta, M., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Gastroenterology (1998) [Pubmed]
  38. Potentiation of aspirin-induced gastric lesions by exposure to cold in rats. Role of acid secretion, mucosal blood flow, and gastric mucosal prostanoid content. Robert, A., Leung, F.W., Kaiser, D.G., Guth, P.H. Gastroenterology (1989) [Pubmed]
  39. Gastric mucosal smooth muscles may explain oscillations in glandular pressure: role of vasoactive intestinal peptide. Synnerstad, I., Ekblad, E., Sundler, F., Holm, L. Gastroenterology (1998) [Pubmed]
  40. Persistent lack of somatostatin receptors in gastric mucosa of healing ulcers in rats. Reubi, J.C., Waser, B., Schmassmann, A., Halter, F. Gastroenterology (1994) [Pubmed]
  41. Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls, and cimetidine in the rat. Szabo, S., Gallagher, G.T., Horner, H.C., Frankel, P.W., Underwood, R.H., Konturek, S.J., Brzozowski, T., Trier, J.S. Gastroenterology (1983) [Pubmed]
  42. Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone. Tarnawski, A., Hollander, D., Stachura, J., Krause, W.J., Gergely, H. Gastroenterology (1985) [Pubmed]
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