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Bonatti, S. et al.

Selection in HAT medium is not a reliable method for the study of reversion from 6-thioguanine resistance to sensitivity.

6-Thioguanine-resistant mutants were induced in V79 Chinese hamster cells with 2-aminopurine, ICR-170 and hycanthone. Samples of mutants of different origin were treated with EMS or 1CR-170 and plated in HAT medium for selection of revertants. In the result, a significant fraction of HAT-resistant clones was not 6-thioguanine-sensitive as would have been expected from a genuine reversion to wild type.[1]

References

Selection in HAT medium is not a reliable method for the study of reversion from 6-thioguanine resistance to sensitivity. Bonatti, S., Di Leonardo, A., Mariani, L., Randazzo, R., Sciandrello, G. Mutat. Res. (1982) [Pubmed]

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