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Chemical Compound Review

hycanthone     1-(2-diethylaminoethylamino)- 4...

Synonyms: Etrenol, Hicantona, Hycanthon, Hycanthonum, Prestwick_698, ...
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Disease relevance of hycanthone


Psychiatry related information on hycanthone


High impact information on hycanthone


Chemical compound and disease context of hycanthone


Biological context of hycanthone


Anatomical context of hycanthone

  • Treatment with mitomycin C (0.05 micrograms/ml), hycanthone (0.1 micrograms/ml) and gamma-radiation (0.1 Gy) revealed a significant (P less than 0.01) increase in frequencies of SCE in DS lymphocytes and in those of their parents as compared to controls [14].
  • Hydroxymethyl analogues, including hycathone (Etrenol), are mutagenic in the absence of microsomes [8].
  • (1) A refined brood-pattern analysis of hycanthone-induced sex-linked recessive lethals confirmed the specific sensitivity of mid- and late spermatids [11].
  • The effects of the antischistosomal drug, hycanthone, on the synaptic transmission at the frog neuromuscular junction were studied [15].
  • A mouse was considered to harbor resistant schistosomes if, three weeks or more after a single intrasmuscular injection of 80 mg/kg hycanthone schistosome eggs were still excreted in the feces, at least one normal worm pair was obtained by perfusion, or miracidia could be seen hatching from the liver [16].

Associations of hycanthone with other chemical compounds


Gene context of hycanthone

  • These findings are in contrast to a recent report of very considerable increases in content or in 5HT acquisition in vitro by hycanthone-exposed parasites [21].
  • Hycanthone is an inhibitor of acetylcholinesterase (ACHE) from S. mansoni, but is less effective against ACHE of mammalian origin [5].
  • Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo [22].
  • Liver and bladder tissues of these animals exhibited a pattern of alteration in the MGMT activity similar to that observed for hycanthone [23].
  • Case report: Severe jaundice following hycanthone [24].

Analytical, diagnostic and therapeutic context of hycanthone


  1. Liver pathology in hycanthone hepatitis. Cohen, C. Gastroenterology (1978) [Pubmed]
  2. Carcinogenic potential of hycanthone in mice and hamsters. Bulay, O., Urman, H., Patil, K., Clayson, D.B., Shubik, P. Int. J. Cancer (1979) [Pubmed]
  3. Evaluation of external-beam radiation therapy plus 5-fluorouracil (5-FU) versus external-beam radiation therapy plus hycanthone (HYC) in confined, unresectable pancreatic cancer. Earle, J.D., Foley, J.F., Wieand, H.S., Kvols, L.K., McKenna, P.J., Krook, J.E., Tschetter, L.K., Schutt, A.J., Twito, D.I. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  4. Hycanthone dose-response in treatment of schistosomiasis mansoni in St. Lucia. Cook, J.A., Jordan, P., Armitage, P. Am. J. Trop. Med. Hyg. (1976) [Pubmed]
  5. Anticholinergic properties of the antischistosomal drug hycanthone. Hillman, G.R., Senft, A.W. Am. J. Trop. Med. Hyg. (1975) [Pubmed]
  6. Early steps in mutagenesis by hycanthone. Bases, R., Mendez, F., Elequin, F., Liebeskind, D., Kozin, A., Neubort, S. Cancer Res. (1978) [Pubmed]
  7. The treatment of schistosomiasis mansoni in Murang'a District, Kenya: a double blind controlled trial of three hycanthone regimens and oxamniquine. Rees, P.H., Bowry, H.N., Roberts, J.M., Thuku, J.J. Am. J. Trop. Med. Hyg. (1975) [Pubmed]
  8. Microsomal activation to mutagens of antischistosomal methyl thioxanthenones and initial tests on a possibly non-mutagenic analogue. Hartman, P.E., Hulbert, P.B., Bueding, E., Taylor, D.D. Mutat. Res. (1975) [Pubmed]
  9. Susceptibility to chemotherapeutic agents of strains of Schistosoma mansoni isolated from treated and untreated patients. Araujo, N., Katz, N., Pinto Dias, E., de Souza, C.P. Am. J. Trop. Med. Hyg. (1980) [Pubmed]
  10. Preferential intercalation at AT sequences in DNA by lucanthone, hycanthone, and indazole analogs. A footprinting study. Bailly, C., Waring, M.J. Biochemistry (1993) [Pubmed]
  11. Mutagenicity of hycanthone in Drosophila: additional results and a comparison with some analogs. Kramers, P.G. Mutat. Res. (1981) [Pubmed]
  12. A genomic change associated with the development of resistance to hycanthone in Schistosoma mansoni. Brindley, P.J., Lewis, F.A., McCutchan, T.F., Bueding, E., Sher, A. Mol. Biochem. Parasitol. (1989) [Pubmed]
  13. Binding of tritiated hycanthone and hycanthone N-methylcarbamate to macromolecules of drug-sensitive and drug-resistant schistosomes. Pica-Mattoccia, L., Cioli, D., Archer, S. Mol. Biochem. Parasitol. (1988) [Pubmed]
  14. Sister-chromatid exchanges in lymphocytes from infants with Down's syndrome. Shubber, E.K., Hamami, H.A., Allak, B.M., Khaleel, A.H. Mutat. Res. (1991) [Pubmed]
  15. Effects of hycanthone on the neuromuscular transmission. Enomoto, K., Edwards, C. Eur. J. Pharmacol. (1985) [Pubmed]
  16. Genetic analysis of hycanthone resistance in Schistosoma mansoni. Cioli, D., Pica Mattoccia, L. Am. J. Trop. Med. Hyg. (1984) [Pubmed]
  17. Acetylcholine receptors in Schistosoma Mansoni: visualization and blockade by hycanthone. Hillman, G.R., Gibler, W.B. Biochem. Pharmacol. (1975) [Pubmed]
  18. Caffeine interactions with methyl methanesulphonate, hycanthone, benlate, and cadmium chloride in chromosomal meiotic segregation of Saccharomyces cerevisiae. Sora, S., Melchioretto, P., Primignani, P., Agostoni Carbone, M.L. Mutat. Res. (1988) [Pubmed]
  19. Some aspects of the detection of potential mutagenic agents in Drosophila. Vogel, E. Mutat. Res. (1975) [Pubmed]
  20. Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro. Mattoccia, L.P., Lelli, A., Cioli, D. Mol. Biochem. Parasitol. (1981) [Pubmed]
  21. Influence of hycanthone on morphology and serotonin uptake of Schistosome mansoni. Senft, A.W., Senft, D.G., Hillman, G.R., Polk, D., Kryger, S. Am. J. Trop. Med. Hyg. (1976) [Pubmed]
  22. Reversing multidrug resistance in L1210 tumor cells by hycanthone or chlorophenoxamine in vitro and in vivo. Efferth, T., Klett, T., Mattern, J., Osswald, H., Pommerenke, E.W., Stöhr, M., Volm, M. Anticancer Res. (1991) [Pubmed]
  23. O6-methylguanine and O6-methylguanine-DNA [corrected] methyltransferase activity in tissues of BDF-1 mice treated with antiparasitic drugs. Badawi, A.F. Toxicol. Lett. (1998) [Pubmed]
  24. Case report: Severe jaundice following hycanthone. Ward, J.M. The Central African journal of medicine. (1975) [Pubmed]
  25. Antimuscarinic activities of hycanthone analogs: possible relationship with animal toxicity. Gordon, R.K., Chiang, P.K. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  26. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Pica Mattoccia, L., Cioli, D. Mol. Biochem. Parasitol. (1983) [Pubmed]
  27. A study of the mode of action of hycanthone against Schistosoma mansoni in vivo and in vitro. Cioli, D., Knopf, P.M. Am. J. Trop. Med. Hyg. (1980) [Pubmed]
  28. Plasma and tissue concentrations of hycanthone in the mouse determined by reversed-phase high-performance liquid chromatography. Moore, E.D., Powis, G. J. Chromatogr. (1980) [Pubmed]
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