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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Release tags: a new class of analytical reagents.

Release tags are novel compounds made up of three molecular groups: "signal," "release," and "reactivity." The signal group is the detected part of the tag, the release group provides a site for specific covalent cleavage, and the reactivity group attaches the tag to a substance of interest. The general purpose of release tags is to function as molecular labels, analogous to radioisotopes. Release tags also extend the applicability of gas-phase electrophores as signal groups to the analysis of nonvolatile substances. These electrophores are measured with high sensitivity and specificity by gas chromatography with electron-capture detection (GC- ECD). Because extensive multiplicity is potentially available with GC- ECD electrophores, many analogous but distinctive release tags can be used simultaneously as labels in a given assay. In this paper, we use N-pentafluorobenzoylmethionylglycine-N-hydroxysuccinimide ester, our first GC- ECD release tag, to determine thyroxin in serum by a method called "labeling analysis," which involves the principle of isotope-derivative analysis.[1]


  1. Release tags: a new class of analytical reagents. Joppich-Kuhn, R., Joppich, M., Giese, R.W. Clin. Chem. (1982) [Pubmed]
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