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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Management of asymptomatic hyperuricemia.

Although the incidence of gout, renal stones, or both is increased in patients with hyperuricemia, there is no evidence that long-term therapy offers any substantial long-term benefits. Recent data also suggest that no clear relationship exists between hyperuricemia and the development of interstitial nephritis (so-called urate nephropathy). Finally, the relationship between elevations in the serum concentration of uric acid and the risk of developing cardiovascular disease remains undefined. It is recommended that, in a patient with asymptomatic hyperuricemia, a conservative approach be taken and hypouricemic therapy not be instituted as a matter of routine.[1]


  1. Management of asymptomatic hyperuricemia. Duffy, W.B., Senekjian, H.O., Knight, T.F., Weinman, E.J. JAMA (1981) [Pubmed]
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