Management of asymptomatic hyperuricemia.
Although the incidence of gout, renal stones, or both is increased in patients with hyperuricemia, there is no evidence that long-term therapy offers any substantial long-term benefits. Recent data also suggest that no clear relationship exists between hyperuricemia and the development of interstitial nephritis (so-called urate nephropathy). Finally, the relationship between elevations in the serum concentration of uric acid and the risk of developing cardiovascular disease remains undefined. It is recommended that, in a patient with asymptomatic hyperuricemia, a conservative approach be taken and hypouricemic therapy not be instituted as a matter of routine.[1]References
- Management of asymptomatic hyperuricemia. Duffy, W.B., Senekjian, H.O., Knight, T.F., Weinman, E.J. JAMA (1981) [Pubmed]
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