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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bile salt transport in the Dubin-Johnson syndrome.

Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.[1]


  1. Bile salt transport in the Dubin-Johnson syndrome. Douglas, J.G., Beckett, G.J., Percy-Robb, I.W., Finlayson, N.D. Gut (1980) [Pubmed]
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