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Chemical Compound Review

Bile salt     4-[(3R,5S,7R,12S)-3,7,12- trihydroxy-10,13...

Synonyms: C01558
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Disease relevance of C01558


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High impact information on C01558


Chemical compound and disease context of C01558


Biological context of C01558


Anatomical context of C01558


Associations of C01558 with other chemical compounds

  • Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids [23].
  • RESULTS: Bile acid perfusion did not significantly alter stimulated pancreatic enzyme, bilirubin or bile acid output or plasma CCK [24].
  • Bile acid breath tests and lactose tolerance tests were not, however, reliable indicators of jejunal bacterial overgrowth [25].
  • The presence of a hydroxy group at the C-23 position increased the acidity of the BA and this accounted for poor absorption within the biliary tree and efficient biliary secretion without the need for conjugation [26].
  • These experiments are consistent with the hypothesis that sn-1 palmitoyl L species are subselected for bile, in part, by physical-chemical interactions of intracellular BS concentrations with Ch-poor membranes and that the subsequent evolution of Ch-rich vesicles and Ch-saturated mixed micelles occurs via a transitional hexagonal (rod) phase [27].

Gene context of C01558


Analytical, diagnostic and therapeutic context of C01558




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  4. Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians. Gälman, C., Miquel, J.F., Pérez, R.M., Einarsson, C., Ståhle, L., Marshall, G., Nervi, F., Rudling, M. Gastroenterology (2004) [Pubmed]
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  11. Bile acid-induced increase in bile acid-independent flow and plasma membrane NaK-ATPase activity in rat liver. Wannagat, R.J., Adler, R.D., Ockner, R.K. J. Clin. Invest. (1978) [Pubmed]
  12. Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man. Malagelada, J.R., DiMagno, E.P., Summerskill, W.H., Go, V.L. J. Clin. Invest. (1976) [Pubmed]
  13. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy [see comemnts]. Brites, D., Rodrigues, C.M. J. Hepatol. (1998) [Pubmed]
  14. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Plösch, T., van der Veen, J.N., Havinga, R., Huijkman, N.C., Bloks, V.W., Kuipers, F. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  15. Taurine and cholestasis associated to TPN. Experimental study in rabbit model. Moran, J.M., Salas, J., Botello, F., Macià, E., Climent, V. Pediatr. Surg. Int. (2005) [Pubmed]
  16. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes. Roberts, L.R., Kurosawa, H., Bronk, S.F., Fesmier, P.J., Agellon, L.B., Leung, W.Y., Mao, F., Gores, G.J. Gastroenterology (1997) [Pubmed]
  17. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Denson, L.A., Sturm, E., Echevarria, W., Zimmerman, T.L., Makishima, M., Mangelsdorf, D.J., Karpen, S.J. Gastroenterology (2001) [Pubmed]
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  20. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Setchell, K.D., Rodrigues, C.M., Clerici, C., Solinas, A., Morelli, A., Gartung, C., Boyer, J. Gastroenterology (1997) [Pubmed]
  21. Bile acid metabolism in benign recurrent intrahepatic cholestasis. Comparative studies on the icteric and anicteric phases of a single case. Endo, T., Uchida, K., Amuro, Y., Higashino, K., Yamamura, Y. Gastroenterology (1979) [Pubmed]
  22. Bile acid transport by basal membrane vesicles of human term placental trophoblast. Marin, J.J., Serrano, M.A., el-Mir, M.Y., Eleno, N., Boyd, C.A. Gastroenterology (1990) [Pubmed]
  23. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. Davis, R.A., Highsmith, W.E., McNeal, M.M., Schexnayder, J.A., Kuan, J.C. J. Biol. Chem. (1983) [Pubmed]
  24. Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids. Koop, I., Schindler, M., Bosshammer, A., Scheibner, J., Stange, E., Koop, H. Gut (1996) [Pubmed]
  25. Dysfunction of the continent ileostomy: clinical features and bacteriology. Kelly, D.G., Phillips, S.F., Kelly, K.A., Weinstein, W.M., Gilchrist, M.J. Gut (1983) [Pubmed]
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  27. Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation. Cohen, D.E., Angelico, M., Carey, M.C. J. Lipid Res. (1990) [Pubmed]
  28. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. Qiao, D., Chen, W., Stratagoules, E.D., Martinez, J.D. J. Biol. Chem. (2000) [Pubmed]
  29. Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Lam, P., Wang, R., Ling, V. Biochemistry (2005) [Pubmed]
  30. Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. Schwarz, M., Russell, D.W., Dietschy, J.M., Turley, S.D. J. Lipid Res. (2001) [Pubmed]
  31. Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes. Qin, P., Borges-Marcucci, L.A., Evans, M.J., Harnish, D.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  32. Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Shekels, L.L., Lyftogt, C.T., Ho, S.B. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  33. Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. Stange, E.F., Scheibner, J., Ditschuneit, H. J. Clin. Invest. (1989) [Pubmed]
  34. Bile salt deconjugation breath tests. King, C.E., Toskes, P.P. Gastroenterology (1978) [Pubmed]
  35. Reflux-related gastric mucosal injury is associated with increased mucosal histamine content in humans. Bechi, P., Amorosi, A., Mazzanti, R., Dei, R., Bianchi, S., Mugnai, L., Masini, E. Gastroenterology (1993) [Pubmed]
  36. Bile acid conjugation in organ culture of human fetal liver. Haber, L.R., Vaupshas, V., Vitullo, B.B., Seemayer, T.A., de Belle, R.C. Gastroenterology (1978) [Pubmed]
  37. Evidence for an ATP-dependent bile acid transport protein other than the canalicular liver ecto-ATPase in rats. Luther, T.T., Hammerman, P., Rahmaoui, C.M., Lee, P.P., Sela-Herman, S., Matula, G.S., Ananthanarayanan, M., Suchy, F.J., Cavalieri, R.R., Lomri, N., Scharschmidt, B.F. Gastroenterology (1997) [Pubmed]
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