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Miner, J.H. et al.

Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues.

We have identified a fifth member of the alpha subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of alpha 5 to the only known Drosophila alpha chain, suggesting that the ancestral alpha gene was more similar to alpha 5 than to alpha 1-4. Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae.[1]

References

Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues. Miner, J.H., Lewis, R.M., Sanes, J.R. J. Biol. Chem. (1995) [Pubmed]

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