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MeSH Review

Cloning, Molecular

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Disease relevance of Cloning, Molecular


High impact information on Cloning, Molecular

  • Molecular cloning of NCR revealed novel members of the Ig superfamily displaying a low degree of similarity to each other and to known human molecules [6].
  • Molecular cloning of HLA-C- and HLA-B-specific receptors has revealed new members of the immunoglobulin superfamily with two or three Ig-like domains, respectively, in their extracellular portion [7].
  • The molecular cloning of the C5a receptor places this molecule in the superfamily of G-protein coupled receptors [8].
  • Electrophysiological studies have detailed the properties of the Na(+), Ca(2+), and K(+) currents that generate cardiac action potentials, and molecular cloning has revealed a large number of pore forming (alpha) and accessory (beta, delta, and gamma) subunits thought to contribute to the formation of these channels [9].
  • One of them binds specifically to methylated DNA in vitro and molecular cloning reveals a similarity to a known methyl CpG-binding protein [10].

Chemical compound and disease context of Cloning, Molecular


Biological context of Cloning, Molecular


Anatomical context of Cloning, Molecular


Associations of Cloning, Molecular with chemical compounds


Gene context of Cloning, Molecular


Analytical, diagnostic and therapeutic context of Cloning, Molecular


  1. Amplification and Molecular Cloning of HTLV-I Sequences from DNA of Multiple Sclerosis Patients. Correction. Reddy, E.P. Science (1989) [Pubmed]
  2. Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ. Chazenbalk, G.D., Portolano, S., Russo, D., Hutchison, J.S., Rapoport, B., McLachlan, S. J. Clin. Invest. (1993) [Pubmed]
  3. The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors. Pan, L.C., Price, P.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene. Yen, T.T., Gill, A.M., Frigeri, L.G., Barsh, G.S., Wolff, G.L. FASEB J. (1994) [Pubmed]
  5. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. Velasco, G., Ferrando, A.A., Puente, X.S., Sánchez, L.M., López-Otín, C. J. Biol. Chem. (1994) [Pubmed]
  6. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M.C., Biassoni, R., Moretta, L. Annu. Rev. Immunol. (2001) [Pubmed]
  7. Receptors for HLA class-I molecules in human natural killer cells. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M.C., Moretta, L. Annu. Rev. Immunol. (1996) [Pubmed]
  8. C5A anaphylatoxin and its seven transmembrane-segment receptor. Gerard, C., Gerard, N.P. Annu. Rev. Immunol. (1994) [Pubmed]
  9. Molecular physiology of cardiac repolarization. Nerbonne, J.M., Kass, R.S. Physiol. Rev. (2005) [Pubmed]
  10. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Wade, P.A., Gegonne, A., Jones, P.L., Ballestar, E., Aubry, F., Wolffe, A.P. Nat. Genet. (1999) [Pubmed]
  11. Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody. Björk, P., Jönsson, U., Svedberg, H., Larsson, K., Lind, P., Dillner, J., Hedlund, G., Dohlsten, M., Kalland, T. J. Biol. Chem. (1993) [Pubmed]
  12. The MglA component of the binding protein-dependent galactose transport system of Salmonella typhimurium is a galactose-stimulated ATPase. Richarme, G., el Yaagoubi, A., Kohiyama, M. J. Biol. Chem. (1993) [Pubmed]
  13. Copper/topa quinone-containing histamine oxidase from Arthrobacter globiformis. Molecular cloning and sequencing, overproduction of precursor enzyme, and generation of topa quinone cofactor. Choi, Y.H., Matsuzaki, R., Fukui, T., Shimizu, E., Yorifuji, T., Sato, H., Ozaki, Y., Tanizawa, K. J. Biol. Chem. (1995) [Pubmed]
  14. Molecular cloning and characterization of sphingolipid ceramide N-deacylase from a marine bacterium, Shewanella alga G8. Furusato, M., Sueyoshi, N., Mitsutake, S., Sakaguchi, K., Kita, K., Okino, N., Ichinose, S., Omori, A., Ito, M. J. Biol. Chem. (2002) [Pubmed]
  15. Identification and molecular cloning of a novel glycoside hydrolase family of core 1 type O-glycan-specific endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum. Fujita, K., Oura, F., Nagamine, N., Katayama, T., Hiratake, J., Sakata, K., Kumagai, H., Yamamoto, K. J. Biol. Chem. (2005) [Pubmed]
  16. Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. Yamanashi, Y., Baltimore, D. Cell (1997) [Pubmed]
  17. Nuclear receptor that identifies a novel retinoic acid response pathway. Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., Evans, R.M. Nature (1990) [Pubmed]
  18. Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo. Preiss, A., Rosenberg, U.B., Kienlin, A., Seifert, E., Jäckle, H. Nature (1985) [Pubmed]
  19. A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease. DeLotto, R., Spierer, P. Nature (1986) [Pubmed]
  20. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Cheng, J., Zhou, T., Liu, C., Shapiro, J.P., Brauer, M.J., Kiefer, M.C., Barr, P.J., Mountz, J.D. Science (1994) [Pubmed]
  21. Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Dejean, A., Bougueleret, L., Grzeschik, K.H., Tiollais, P. Nature (1986) [Pubmed]
  22. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Minty, A., Chalon, P., Derocq, J.M., Dumont, X., Guillemot, J.C., Kaghad, M., Labit, C., Leplatois, P., Liauzun, P., Miloux, B. Nature (1993) [Pubmed]
  23. Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Caras, I.W., Davitz, M.A., Rhee, L., Weddell, G., Martin, D.W., Nussenzweig, V. Nature (1987) [Pubmed]
  24. Presence of an SH2 domain in the actin-binding protein tensin. Davis, S., Lu, M.L., Lo, S.H., Lin, S., Butler, J.A., Druker, B.J., Roberts, T.M., An, Q., Chen, L.B. Science (1991) [Pubmed]
  25. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. Falco, M., Biassoni, R., Bottino, C., Vitale, M., Sivori, S., Augugliaro, R., Moretta, L., Moretta, A. J. Exp. Med. (1999) [Pubmed]
  26. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Kashiwabuchi, N., Ikeda, K., Araki, K., Hirano, T., Shibuki, K., Takayama, C., Inoue, Y., Kutsuwada, T., Yagi, T., Kang, Y. Cell (1995) [Pubmed]
  27. The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis. Pavlidis, P., Ramaswami, M., Tanouye, M.A. Cell (1994) [Pubmed]
  28. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Sokoloff, P., Giros, B., Martres, M.P., Bouthenet, M.L., Schwartz, J.C. Nature (1990) [Pubmed]
  29. Molecular cloning and characterization of an insulin-regulatable glucose transporter. James, D.E., Strube, M., Mueckler, M. Nature (1989) [Pubmed]
  30. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Shou, C., Farnsworth, C.L., Neel, B.G., Feig, L.A. Nature (1992) [Pubmed]
  31. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Hoey, T., Weinzierl, R.O., Gill, G., Chen, J.L., Dynlacht, B.D., Tjian, R. Cell (1993) [Pubmed]
  32. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Akira, S., Nishio, Y., Inoue, M., Wang, X.J., Wei, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., Kishimoto, T. Cell (1994) [Pubmed]
  33. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Tsuda, L., Inoue, Y.H., Yoo, M.A., Mizuno, M., Hata, M., Lim, Y.M., Adachi-Yamada, T., Ryo, H., Masamune, Y., Nishida, Y. Cell (1993) [Pubmed]
  34. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Anderson, D.M., Lyman, S.D., Baird, A., Wignall, J.M., Eisenman, J., Rauch, C., March, C.J., Boswell, H.S., Gimpel, S.D., Cosman, D. Cell (1990) [Pubmed]
  35. The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis. Clark, S.E., Williams, R.W., Meyerowitz, E.M. Cell (1997) [Pubmed]
  36. Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients. Reddy, E.P., Sandberg-Wollheim, M., Mettus, R.V., Ray, P.E., DeFreitas, E., Koprowski, H. Science (1989) [Pubmed]
  37. Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. Willis, T.G., Jadayel, D.M., Coignet, L.J., Abdul-Rauf, M., Treleaven, J.G., Catovsky, D., Dyer, M.J. Blood (1997) [Pubmed]
  38. Induction of acetylcholinesterase expression during apoptosis in various cell types. Zhang, X.J., Yang, L., Zhao, Q., Caen, J.P., He, H.Y., Jin, Q.H., Guo, L.H., Alemany, M., Zhang, L.Y., Shi, Y.F. Cell Death Differ. (2002) [Pubmed]
  39. Immunolocalization of G protein alpha-subunits in the Drosophila CNS. Wolfgang, W.J., Quan, F., Goldsmith, P., Unson, C., Spiegel, A., Forte, M. J. Neurosci. (1990) [Pubmed]
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