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Straus, E. et al.

Cholecystokinin in the brains of obese and nonobese mice.

Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.[1]

References

Cholecystokinin in the brains of obese and nonobese mice. Straus, E., Yalow, R.S. Science (1979) [Pubmed]

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