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MeSH Review

Mice, Obese

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Disease relevance of Mice, Obese


High impact information on Mice, Obese

  • Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver in obese mice [6].
  • First, MCH stimulates feeding when injected directly into rat brains; second, the messenger RNA for the MCH precursor is upregulated in the hypothalamus of genetically obese mice and in fasted animals; and third, mice lacking MCH eat less and are lean [7].
  • Peripheral administration of leptin to obese mice stimulates CART mRNA expression [8].
  • The TNFalpha-deficient obese mice had lower levels of circulating free fatty acids, and were protected from the obesity-related reduction in the insulin receptor signalling in muscle and fat tissues [1].
  • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists [9].

Chemical compound and disease context of Mice, Obese


Biological context of Mice, Obese


Anatomical context of Mice, Obese


Associations of Mice, Obese with chemical compounds


Gene context of Mice, Obese


Analytical, diagnostic and therapeutic context of Mice, Obese


  1. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Uysal, K.T., Wiesbrock, S.M., Marino, M.W., Hotamisligil, G.S. Nature (1997) [Pubmed]
  2. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., Burn, P. Science (1995) [Pubmed]
  3. Weight loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor/cachectin activity in peritoneal macrophages. Lathey, J.L., Oldstone, M.B. Am. J. Pathol. (1988) [Pubmed]
  4. Age dependent effects of oxytetracycline in ob/ob mice. Dubuc, P.U., Willis, P.L. Diabetologia (1978) [Pubmed]
  5. The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. Enser, M., Roberts, J.L. Biochem. J. (1982) [Pubmed]
  6. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M.L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., Kadowaki, T. Nat. Med. (2001) [Pubmed]
  7. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Chambers, J., Ames, R.S., Bergsma, D., Muir, A., Fitzgerald, L.R., Hervieu, G., Dytko, G.M., Foley, J.J., Martin, J., Liu, W.S., Park, J., Ellis, C., Ganguly, S., Konchar, S., Cluderay, J., Leslie, R., Wilson, S., Sarau, H.M. Nature (1999) [Pubmed]
  8. Hypothalamic CART is a new anorectic peptide regulated by leptin. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christjansen, K.N., Wulff, B.S., Clausen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J., Hastrup, S. Nature (1998) [Pubmed]
  9. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Mukherjee, R., Davies, P.J., Crombie, D.L., Bischoff, E.D., Cesario, R.M., Jow, L., Hamann, L.G., Boehm, M.F., Mondon, C.E., Nadzan, A.M., Paterniti, J.R., Heyman, R.A. Nature (1997) [Pubmed]
  10. Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., De Lorenzi, R., Krone, W., Rajewsky, K., Brüning, J.C. J. Clin. Invest. (2004) [Pubmed]
  11. Effect of an alpha-glycosidase inhibitor on experimentally-induced obesity in mice. Le Marchand-Brustel, Y., Rochet, N., Grémeaux, T., Marot, I., Van Obberghen, E. Diabetologia (1990) [Pubmed]
  12. Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice. Nielsen, J.A., Chapin, D.S., Johnson, J.L., Torgersen, L.K. Am. J. Clin. Nutr. (1992) [Pubmed]
  13. Changes in the lipogenic response to feeding of liver, white adipose tissue and brown adipose tissue during the development of obesity in the gold-thioglucose-injected mouse. Cooney, G.J., Vanner, M.A., Nicks, J.L., Williams, P.F., Caterson, I.D. Biochem. J. (1989) [Pubmed]
  14. Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine. Lowell, B.B., Napolitano, A., Usher, P., Dulloo, A.G., Rosen, B.S., Spiegelman, B.M., Flier, J.S. Endocrinology (1990) [Pubmed]
  15. Role of Foxa-2 in adipocyte metabolism and differentiation. Wolfrum, C., Shih, D.Q., Kuwajima, S., Norris, A.W., Kahn, C.R., Stoffel, M. J. Clin. Invest. (2003) [Pubmed]
  16. Insulin depletion leads to adipose-specific cell death in obese but not lean mice. Loftus, T.M., Kuhajda, F.P., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha. Hwang, C.S., Mandrup, S., MacDougald, O.A., Geiman, D.E., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  18. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Yu, X.X., Murray, S.F., Pandey, S.K., Booten, S.L., Bao, D., Song, X.Z., Kelly, S., Chen, S., McKay, R., Monia, B.P., Bhanot, S. Hepatology (2005) [Pubmed]
  19. Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice. Robin, M.A., Demeilliers, C., Sutton, A., Paradis, V., Maisonneuve, C., Dubois, S., Poirel, O., Lettéron, P., Pessayre, D., Fromenty, B. Hepatology (2005) [Pubmed]
  20. Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Le Marchand-Brustel, Y., Grémeaux, T., Ballotti, R., Van Obberghen, E. Nature (1985) [Pubmed]
  21. Tissue factor gene expression in the adipose tissues of obese mice. Samad, F., Pandey, M., Loskutoff, D.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  22. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Maisonneuve, C., Igoudjil, A., Begriche, K., Lettéron, P., Guimont, M.C., Bastin, J., Laigneau, J.P., Pessayre, D., Fromenty, B. Antivir. Ther. (Lond.) (2004) [Pubmed]
  23. Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling. Young, P.W., Cawthorne, M.A., Coyle, P.J., Holder, J.C., Holman, G.D., Kozka, I.J., Kirkham, D.M., Lister, C.A., Smith, S.A. Diabetes (1995) [Pubmed]
  24. Selective deletion of leptin receptor in neurons leads to obesity. Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Mombaerts, P., Friedman, J.M. J. Clin. Invest. (2001) [Pubmed]
  25. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Cope, K., Risby, T., Diehl, A.M. Gastroenterology (2000) [Pubmed]
  26. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Yang, S.Q., Lin, H.Z., Lane, M.D., Clemens, M., Diehl, A.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  27. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. Lin, X., Taguchi, A., Park, S., Kushner, J.A., Li, F., Li, Y., White, M.F. J. Clin. Invest. (2004) [Pubmed]
  28. Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Shimokawa, T., Kumar, M.V., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  29. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J., Yamada, N., Shimano, H. Hepatology (2003) [Pubmed]
  30. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Rajala, M.W., Qi, Y., Patel, H.R., Takahashi, N., Banerjee, R., Pajvani, U.B., Sinha, M.K., Gingerich, R.L., Scherer, P.E., Ahima, R.S. Diabetes (2004) [Pubmed]
  31. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Muzzin, P., Eisensmith, R.C., Copeland, K.C., Woo, S.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice. Ventre, J., Doebber, T., Wu, M., MacNaul, K., Stevens, K., Pasparakis, M., Kollias, G., Moller, D.E. Diabetes (1997) [Pubmed]
  33. Anorexia after adrenalectomy in gold thioglucose-treated obese mice. Debons, A.F., Das, K.C., Fuhr, B., Siclari, E. Endocrinology (1983) [Pubmed]
  34. The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese--hyperglycaemic (ob/ob) and lean mice. Enser, M. Biochem. J. (1979) [Pubmed]
  35. The RAGE axis in early diabetic retinopathy. Barile, G.R., Pachydaki, S.I., Tari, S.R., Lee, S.E., Donmoyer, C.M., Ma, W., Rong, L.L., Buciarelli, L.G., Wendt, T., Hörig, H., Hudson, B.I., Qu, W., Weinberg, A.D., Yan, S.F., Schmidt, A.M. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
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