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MeSH Review

Mice, Obese

 
 
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Disease relevance of Mice, Obese

 

High impact information on Mice, Obese

  • Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver in obese mice [6].
  • First, MCH stimulates feeding when injected directly into rat brains; second, the messenger RNA for the MCH precursor is upregulated in the hypothalamus of genetically obese mice and in fasted animals; and third, mice lacking MCH eat less and are lean [7].
  • Peripheral administration of leptin to obese mice stimulates CART mRNA expression [8].
  • The TNFalpha-deficient obese mice had lower levels of circulating free fatty acids, and were protected from the obesity-related reduction in the insulin receptor signalling in muscle and fat tissues [1].
  • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists [9].
 

Chemical compound and disease context of Mice, Obese

 

Biological context of Mice, Obese

 

Anatomical context of Mice, Obese

 

Associations of Mice, Obese with chemical compounds

 

Gene context of Mice, Obese

 

Analytical, diagnostic and therapeutic context of Mice, Obese

References

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  2. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., Burn, P. Science (1995) [Pubmed]
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  13. Changes in the lipogenic response to feeding of liver, white adipose tissue and brown adipose tissue during the development of obesity in the gold-thioglucose-injected mouse. Cooney, G.J., Vanner, M.A., Nicks, J.L., Williams, P.F., Caterson, I.D. Biochem. J. (1989) [Pubmed]
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  18. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Yu, X.X., Murray, S.F., Pandey, S.K., Booten, S.L., Bao, D., Song, X.Z., Kelly, S., Chen, S., McKay, R., Monia, B.P., Bhanot, S. Hepatology (2005) [Pubmed]
  19. Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice. Robin, M.A., Demeilliers, C., Sutton, A., Paradis, V., Maisonneuve, C., Dubois, S., Poirel, O., Lettéron, P., Pessayre, D., Fromenty, B. Hepatology (2005) [Pubmed]
  20. Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Le Marchand-Brustel, Y., Grémeaux, T., Ballotti, R., Van Obberghen, E. Nature (1985) [Pubmed]
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  24. Selective deletion of leptin receptor in neurons leads to obesity. Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Mombaerts, P., Friedman, J.M. J. Clin. Invest. (2001) [Pubmed]
  25. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Cope, K., Risby, T., Diehl, A.M. Gastroenterology (2000) [Pubmed]
  26. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Yang, S.Q., Lin, H.Z., Lane, M.D., Clemens, M., Diehl, A.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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