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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sertraline for social phobia: a double-blind, placebo-controlled crossover study.

OBJECTIVE: The authors examined the efficacy of sertraline in the treatment of social phobia. METHOD: In a double-blind crossover study, 12 outpatients were randomly assigned to 10 weeks of sertraline (50-200 mg/day, flexible dosing) and 10 weeks of placebo. RESULTS: A statistically significant improvement in scores on the Liebowitz Social Anxiety Scale was found with sertraline but not with placebo. There was no significant difference between scores obtained with computer- and clinician-administered versions of the Liebowitz Social Anxiety Scale, and the majority of patients preferred to be interviewed by the computer. CONCLUSIONS: Sertraline seems a safe and effective treatment for social phobia, and computer administration may be a preferable mode of assessment with socially phobic patients.[1]


  1. Sertraline for social phobia: a double-blind, placebo-controlled crossover study. Katzelnick, D.J., Kobak, K.A., Greist, J.H., Jefferson, J.W., Mantle, J.M., Serlin, R.C. The American journal of psychiatry. (1995) [Pubmed]
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