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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis.

The protein encoded by the yeast gene SPT14 shows high sequence similarity to the human protein, PIG-A, whose loss of activity is at the origin of the disease paroxysmal nocturnal hemoglobinuria. The symptoms of this disease are apparently due to a loss of cell surface, glycosylphosphatidylinositol (GPI)-anchored proteins. Like PIG-A mutant cells, spt14 mutant cells are defective in GPI anchoring due to a defect in the synthesis of GlcNAc-PI, the first step of GPI synthesis. The spt14 mutant causes several other abnormalities including transcriptional defects and a downregulation of inositolphosphoceramide synthesis. We suggest that these defects are indirect results of the loss of GPI anchoring.[1]

References

  1. The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis. Schönbächler, M., Horvath, A., Fassler, J., Riezman, H. EMBO J. (1995) [Pubmed]
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