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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The DXS423E gene in Xp11.21 escapes X chromosome inactivation.

The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.[1]


  1. The DXS423E gene in Xp11.21 escapes X chromosome inactivation. Brown, C.J., Miller, A.P., Carrel, L., Rupert, J.L., Davies, K.E., Willard, H.F. Hum. Mol. Genet. (1995) [Pubmed]
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