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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Duplex and triplex directed DNA cleavage by oligonucleotide-Cu(II)/Co(III) metallodesferal conjugates.

Cu(II) desferal conjugated to d(T)10 at 5'-end is shown to direct the cleavage of single stranded 19-mer target DNA d(TA1GCCCGGCG), with a base preference G > C >> A. In contrast, the corresponding Co(II)-desferal conjugate directed the cleavage specific to only G sites (G12, G16, G17 and G19). Triplex targetting on the duplex 5'-TCCTGATAAAGGAGGAGATGAAGAAAAAATGA-3': 3'-AGGACTATTTCCTCCTCTACTTCTTTTTTACT-5', using Cu(II) desferal conjugated to 5'-end of 3'-TTTCCTCCTCT-5' directed the cleavage at G5.[1]

References

  1. Duplex and triplex directed DNA cleavage by oligonucleotide-Cu(II)/Co(III) metallodesferal conjugates. Joshi, R.R., Ganesh, K.N. Biochim. Biophys. Acta (1994) [Pubmed]
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