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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The SNF/ SWI family of global transcriptional activators.

The yeast SNF/SWI proteins have a global role in transcriptional activation. This set of five proteins assists many gene-specific activators, most likely by altering chromatin structure to relieve repression. Recent work shows that the SNF/ SWI proteins function together in a multiprotein complex and that SNF2 has DNA-dependent ATPase activity. SNF/ SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation.[1]


  1. The SNF/SWI family of global transcriptional activators. Carlson, M., Laurent, B.C. Curr. Opin. Cell Biol. (1994) [Pubmed]
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