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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity.

A diversity of high-affinity oligosaccharide ligands are identified for NKR-P1, a membrane protein on natural killer (NK) cells which contains an extracellular Ca(2+)-dependent lectin domain. Interactions of such oligosaccharides on the target cell surface with NKR-P1 on the killer cell surface are crucial both for target cell recognition and for delivery of stimulatory or inhibitory signals linked to the NK cytolytic machinery. NK-resistant tumour cells are rendered susceptible by preincubation with liposomes expressing NKR-P1 ligands, suggesting that purging of tumour or virally infected cells in vivo may be a therapeutic possibility.[1]

References

  1. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Bezouska, K., Yuen, C.T., O'Brien, J., Childs, R.A., Chai, W., Lawson, A.M., Drbal, K., Fiserová, A., Pospísil, M., Feizi, T. Nature (1994) [Pubmed]
 
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