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Killer Cells, Natural

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Disease relevance of Killer Cells, Natural

  • The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection [1].
  • TWEAK-/- mice had overabundant natural killer (NK) cells and displayed hypersensitivity to bacterial endotoxin, with their innate immune cells producing excess interferon (IFN)-gamma and interleukin (IL)-12 [2].
  • Sera from healthy persons did not contain a detectable level of sFasL, whereas those from patients with large granular lymphocytic (LGL) leukemia and natural killer (NK) cell lymphoma did [3].
  • Specifically, the activity of natural killer (NK) cells, which are involved in the resistance to infections and metastasis, can be suppressed in the presence of ethanol in vitro [4].
  • These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein [5].

Psychiatry related information on Killer Cells, Natural


High impact information on Killer Cells, Natural

  • Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway [12].
  • Their combinatorial expression creates a repertoire of NK cells that surveys the expression of almost every MHC molecule independently, thus antagonizing the spread of pathogens and tumors that subvert innate and adaptive defense by selectively downregulating certain MHC class I molecules [13].
  • Certain CpG motifs (CpG-A) are especially potent at activating NK cells and inducing IFN-alpha production by PDCs, while other motifs (CpG-B) are especially potent B cell activators [14].
  • A direct correlation exists between the surface density of NCR and the ability of NK cells to kill various tumors [15].

Chemical compound and disease context of Killer Cells, Natural


Biological context of Killer Cells, Natural


Anatomical context of Killer Cells, Natural


Associations of Killer Cells, Natural with chemical compounds


Gene context of Killer Cells, Natural


Analytical, diagnostic and therapeutic context of Killer Cells, Natural


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  2. TWEAK attenuates the transition from innate to adaptive immunity. Maecker, H., Varfolomeev, E., Kischkel, F., Lawrence, D., LeBlanc, H., Lee, W., Hurst, S., Danilenko, D., Li, J., Filvaroff, E., Yang, B., Daniel, D., Ashkenazi, A. Cell (2005) [Pubmed]
  3. Fas ligand in human serum. Tanaka, M., Suda, T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M., Tagawa, S., Ohga, S., Hatake, K., Drummond, A.H., Nagata, S. Nat. Med. (1996) [Pubmed]
  4. Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis. Ben-Eliyahu, S., Page, G.G., Yirmiya, R., Taylor, A.N. Nat. Med. (1996) [Pubmed]
  5. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Mandelboim, O., Lieberman, N., Lev, M., Paul, L., Arnon, T.I., Bushkin, Y., Davis, D.M., Strominger, J.L., Yewdell, J.W., Porgador, A. Nature (2001) [Pubmed]
  6. Severe stress, depressive symptoms, and changes in lymphocyte subsets in human immunodeficiency virus-infected men. A 2-year follow-up study. Leserman, J., Petitto, J.M., Perkins, D.O., Folds, J.D., Golden, R.N., Evans, D.L. Arch. Gen. Psychiatry (1997) [Pubmed]
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  15. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M.C., Biassoni, R., Moretta, L. Annu. Rev. Immunol. (2001) [Pubmed]
  16. Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function. Welsh, R.M., Brubaker, J.O., Vargas-Cortes, M., O'Donnell, C.L. J. Exp. Med. (1991) [Pubmed]
  17. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. Lodoen, M., Ogasawara, K., Hamerman, J.A., Arase, H., Houchins, J.P., Mocarski, E.S., Lanier, L.L. J. Exp. Med. (2003) [Pubmed]
  18. Role of natural killer cells in the destruction of circulating tumor emboli. Hanna, N., Fidler, I.J. J. Natl. Cancer Inst. (1980) [Pubmed]
  19. Differential induction of suppressor macrophages by cloned Lewis lung carcinoma variants in mice. Young, M.R., Newby, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  20. Suppression of peripheral blood natural killer cell activity by excess thyroid hormone. Papic, M., Stein-Streilein, J., Zakarija, M., McKenzie, J.M., Guffee, J., Fletcher, M.A. J. Clin. Invest. (1987) [Pubmed]
  21. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A.B., Phillips, J.H., Pekkarinen, P., Lanier, L.L., Timonen, T., Peltonen, L. Nat. Genet. (2000) [Pubmed]
  22. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Brown, K.E., Guest, S.S., Smale, S.T., Hahm, K., Merkenschlager, M., Fisher, A.G. Cell (1997) [Pubmed]
  23. The Ikaros gene is required for the development of all lymphoid lineages. Georgopoulos, K., Bigby, M., Wang, J.H., Molnar, A., Wu, P., Winandy, S., Sharpe, A. Cell (1994) [Pubmed]
  24. Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility. Trimble, W.S., Johnson, P.W., Hozumi, N., Roder, J.C. Nature (1986) [Pubmed]
  25. Homology of perforin to the ninth component of complement (C9). Shinkai, Y., Takio, K., Okumura, K. Nature (1988) [Pubmed]
  26. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Parrish-Novak, J., Dillon, S.R., Nelson, A., Hammond, A., Sprecher, C., Gross, J.A., Johnston, J., Madden, K., Xu, W., West, J., Schrader, S., Burkhead, S., Heipel, M., Brandt, C., Kuijper, J.L., Kramer, J., Conklin, D., Presnell, S.R., Berry, J., Shiota, F., Bort, S., Hambly, K., Mudri, S., Clegg, C., Moore, M., Grant, F.J., Lofton-Day, C., Gilbert, T., Rayond, F., Ching, A., Yao, L., Smith, D., Webster, P., Whitmore, T., Maurer, M., Kaushansky, K., Holly, R.D., Foster, D. Nature (2000) [Pubmed]
  27. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Park, J.K., Rosenstein, Y.J., Remold-O'Donnell, E., Bierer, B.E., Rosen, F.S., Burakoff, S.J. Nature (1991) [Pubmed]
  28. A novel dendritic cell subset involved in tumor immunosurveillance. Taieb, J., Chaput, N., Ménard, C., Apetoh, L., Ullrich, E., Bonmort, M., Péquignot, M., Casares, N., Terme, M., Flament, C., Opolon, P., Lecluse, Y., Métivier, D., Tomasello, E., Vivier, E., Ghiringhelli, F., Martin, F., Klatzmann, D., Poynard, T., Tursz, T., Raposo, G., Yagita, H., Ryffel, B., Kroemer, G., Zitvogel, L. Nat. Med. (2006) [Pubmed]
  29. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Siliciano, R.F., Pratt, J.C., Schmidt, R.E., Ritz, J., Reinherz, E.L. Nature (1985) [Pubmed]
  30. NK cell receptors. Lanier, L.L. Annu. Rev. Immunol. (1998) [Pubmed]
  31. Effect of pravastatin on outcomes after cardiac transplantation. Kobashigawa, J.A., Katznelson, S., Laks, H., Johnson, J.A., Yeatman, L., Wang, X.M., Chia, D., Terasaki, P.I., Sabad, A., Cogert, G.A. N. Engl. J. Med. (1995) [Pubmed]
  32. Hydroxyl radical scavengers inhibit human natural killer cell activity. Suthanthiran, M., Solomon, S.D., Williams, P.S., Rubin, A.L., Novogrodsky, A., Stenzel, K.H. Nature (1984) [Pubmed]
  33. Radiofrequency destruction of the tuberoinfundibular region of hypothalamus permanently abrogates NK cell activity in mice. Forni, G., Bindoni, M., Santoni, A., Belluardo, N., Marchese, A.E., Giovarelli, M. Nature (1983) [Pubmed]
  34. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Waldmann, T.A., Tagaya, Y. Annu. Rev. Immunol. (1999) [Pubmed]
  35. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T.J., Yoshie, O. Cell (1997) [Pubmed]
  36. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Braud, V.M., Allan, D.S., O'Callaghan, C.A., Söderström, K., D'Andrea, A., Ogg, G.S., Lazetic, S., Young, N.T., Bell, J.I., Phillips, J.H., Lanier, L.L., McMichael, A.J. Nature (1998) [Pubmed]
  37. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Melder, R.J., Koenig, G.C., Witwer, B.P., Safabakhsh, N., Munn, L.L., Jain, R.K. Nat. Med. (1996) [Pubmed]
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  39. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Beilke, J.N., Kuhl, N.R., Van Kaer, L., Gill, R.G. Nat. Med. (2005) [Pubmed]
  40. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment. Lin, Y., Goebels, J., Xia, G., Ji, P., Vandeputte, M., Waer, M. Nat. Med. (1998) [Pubmed]
  41. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Binstadt, B.A., Brumbaugh, K.M., Dick, C.J., Scharenberg, A.M., Williams, B.L., Colonna, M., Lanier, L.L., Kinet, J.P., Abraham, R.T., Leibson, P.J. Immunity (1996) [Pubmed]
  42. The binding site of NK receptors on HLA-C molecules. Mandelboim, O., Reyburn, H.T., Sheu, E.G., Vales-Gomez, M., Davis, D.M., Pazmany, L., Strominger, J.L. Immunity (1997) [Pubmed]
  43. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. Chen, S., Kawashima, H., Lowe, J.B., Lanier, L.L., Fukuda, M. J. Exp. Med. (2005) [Pubmed]
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