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Shinotoh, H. et al.

Normal CAG repeat length in the Huntington's disease gene in senile chorea.

There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease ( HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths were normal. These findings support senile chorea as being a distinct clinical entity that is nosologically separate from late-onset HD.[1]

References

Normal CAG repeat length in the Huntington's disease gene in senile chorea. Shinotoh, H., Calne, D.B., Snow, B., Hayward, M., Kremer, B., Theilmann, J., Hayden, M.R. Neurology (1994) [Pubmed]

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