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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Organ changes after intravenous trinonanoin administration in rabbits.

For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C9TG)/long-chain triglyceride (LCT) emulsion was given parenterally to rabbits, providing 46.5% of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C9TG/LCT group macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglycerides, liver phospholipids, adipose tissue and skeletal muscle after C9TG/LCT administration was similar to C8/C10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.[1]

References

  1. Organ changes after intravenous trinonanoin administration in rabbits. Linseisen, J., Wolfram, G. Ann. Nutr. Metab. (1993) [Pubmed]
 
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