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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Adipose Tissue

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Disease relevance of Adipose Tissue


Psychiatry related information on Adipose Tissue


High impact information on Adipose Tissue

  • Regulatory elements that control transcription of the PEPCK-C gene in liver, kidney, and adipose tissue have been delineated, and many of the transcription factors that bind to these elements have been identified [10].
  • A pericellular collagenase directs the 3-dimensional development of white adipose tissue [11].
  • The authors show that remodeling of the extracellular matrix by the matrix metalloproteinase MT1-MMP contributes to the three-dimensional development of white adipose tissue in mice [12].
  • We show here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity [13].
  • In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially [14].

Chemical compound and disease context of Adipose Tissue


Biological context of Adipose Tissue


Anatomical context of Adipose Tissue


Associations of Adipose Tissue with chemical compounds


Gene context of Adipose Tissue

  • Uncoupling protein-2 (UCP2) is a recently identified member of the mitochondrial transporter superfamily that is expressed in many tissues, including adipose tissue [21].
  • Consistent with the observed reduction of adipose tissue mass in fld and fld(2J)mice, wild-type Lpin1 mRNA is expressed at high levels in adipose tissue and is induced during differentiation of 3T3-L1 pre-adipocytes [34].
  • AGPAT2 mRNA is highly expressed in adipose tissue [35].
  • Unexpectedly, Crebbp+/- mice showed markedly reduced weight of white adipose tissue (WAT) but not of other tissues [36].
  • Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1 [37].

Analytical, diagnostic and therapeutic context of Adipose Tissue


  1. In vivo modulation of Hmgic reduces obesity. Anand, A., Chada, K. Nat. Genet. (2000) [Pubmed]
  2. Weight gain after cessation of cigarette smoking. A possible role for adipose-tissue lipoprotein lipase. Carney, R.M., Goldberg, A.P. N. Engl. J. Med. (1984) [Pubmed]
  3. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Magré, J., Delépine, M., Khallouf, E., Gedde-Dahl, T., Van Maldergem, L., Sobel, E., Papp, J., Meier, M., Mégarbané, A., Bachy, A., Verloes, A., d'Abronzo, F.H., Seemanova, E., Assan, R., Baudic, N., Bourut, C., Czernichow, P., Huet, F., Grigorescu, F., de Kerdanet, M., Lacombe, D., Labrune, P., Lanza, M., Loret, H., Matsuda, F., Navarro, J., Nivelon-Chevalier, A., Polak, M., Robert, J.J., Tric, P., Tubiana-Rufi, N., Vigouroux, C., Weissenbach, J., Savasta, S., Maassen, J.A., Trygstad, O., Bogalho, P., Freitas, P., Medina, J.L., Bonnicci, F., Joffe, B.I., Loyson, G., Panz, V.R., Raal, F.J., O'Rahilly, S., Stephenson, T., Kahn, C.R., Lathrop, M., Capeau, J. Nat. Genet. (2001) [Pubmed]
  4. Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women. Eckel, R.H., Yost, T.J. J. Clin. Invest. (1987) [Pubmed]
  5. Leptin and the regulation of body weight in mammals. Friedman, J.M., Halaas, J.L. Nature (1998) [Pubmed]
  6. Lactate and glycerol release from the subcutaneous adipose tissue of obese urban women from South Africa; important metabolic implications. van der Merwe, M.T., Crowther, N.J., Schlaphoff, G.P., Boyd, I.H., Gray, I.P., Joffe, B.I., Lönnroth, P.N. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  7. Physical activity and plasma lipoprotein lipid concentrations in men. Sutherland, W.H., Woodhouse, S.P. Atherosclerosis (1980) [Pubmed]
  8. Occurrence of individual trans-isomeric fatty acids in human myocardium, jejunum and aorta in relation to different degrees of atherosclerosis. Heckers, H., Körner, M., Tüschen, T.W., Melcher, F.W. Atherosclerosis (1977) [Pubmed]
  9. A multifactor analysis of growth in the rat epididymal fat pad. Cleary, M.P., Greenwood, M.R., Brasel, J.A. J. Nutr. (1977) [Pubmed]
  10. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Hanson, R.W., Reshef, L. Annu. Rev. Biochem. (1997) [Pubmed]
  11. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Chun, T.H., Hotary, K.B., Sabeh, F., Saltiel, A.R., Allen, E.D., Weiss, S.J. Cell (2006) [Pubmed]
  12. Forcing the third dimension. Boudreau, N., Weaver, V. Cell (2006) [Pubmed]
  13. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., Evans, R.M. Cell (2003) [Pubmed]
  14. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Libina, N., Berman, J.R., Kenyon, C. Cell (2003) [Pubmed]
  15. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. Chen, H.C., Jensen, D.R., Myers, H.M., Eckel, R.H., Farese, R.V. J. Clin. Invest. (2003) [Pubmed]
  16. Glycerol production in subcutaneous adipose tissue in lean and obese humans. Jansson, P.A., Larsson, A., Smith, U., Lönnroth, P. J. Clin. Invest. (1992) [Pubmed]
  17. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. Vidal-Puig, A., Jimenez-Liñan, M., Lowell, B.B., Hamann, A., Hu, E., Spiegelman, B., Flier, J.S., Moller, D.E. J. Clin. Invest. (1996) [Pubmed]
  18. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M.A., Chui, P.C., Leszyk, J., Straubhaar, J., Czech, M.P., Corvera, S. J. Clin. Invest. (2004) [Pubmed]
  19. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. De Vos, P., Lefebvre, A.M., Miller, S.G., Guerre-Millo, M., Wong, K., Saladin, R., Hamann, L.G., Staels, B., Briggs, M.R., Auwerx, J. J. Clin. Invest. (1996) [Pubmed]
  20. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Stoffel, M., Friedman, J.M. Nat. Genet. (1996) [Pubmed]
  21. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A.D., Patsch, J.R., Krempler, F., Patsch, W. Nat. Genet. (2001) [Pubmed]
  22. Transient increase in obese gene expression after food intake or insulin administration. Saladin, R., De Vos, P., Guerre-Millo, M., Leturque, A., Girard, J., Staels, B., Auwerx, J. Nature (1995) [Pubmed]
  23. Interleukin-6-deficient mice develop mature-onset obesity. Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S.L., Ohlsson, C., Jansson, J.O. Nat. Med. (2002) [Pubmed]
  24. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Berg, A.H., Combs, T.P., Du, X., Brownlee, M., Scherer, P.E. Nat. Med. (2001) [Pubmed]
  25. Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Lauro, D., Kido, Y., Castle, A.L., Zarnowski, M.J., Hayashi, H., Ebina, Y., Accili, D. Nat. Genet. (1998) [Pubmed]
  26. Positional cloning of the mouse obese gene and its human homologue. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M. Nature (1994) [Pubmed]
  27. Incorporation of 32Pi into pyruvate dehydrogenase phosphate in mitochondria from control and insulin-treated adipose tissue. Hughes, W.A., Denton, R.M. Nature (1976) [Pubmed]
  28. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Cook, K.S., Min, H.Y., Johnson, D., Chaplinsky, R.J., Flier, J.S., Hunt, C.R., Spiegelman, B.M. Science (1987) [Pubmed]
  29. Lactate release from the subcutaneous tissue in lean and obese men. Jansson, P.A., Larsson, A., Smith, U., Lönnroth, P. J. Clin. Invest. (1994) [Pubmed]
  30. Increase in lipoprotein lipase during clofibrate treatment of hypertriglyceridemia in patients on hemodialysis. Goldberg, A.P., Applebaum-Bowden, D.M., Bierman, E.L., Hazzard, W.R., Haas, L.B., Sherrard, D.J., Brunzell, J.D., Huttunen, J.K., Ehnholm, C., Nikkila, E.A. N. Engl. J. Med. (1979) [Pubmed]
  31. Complete protein sequence and identification of structural domains of human apolipoprotein B. Knott, T.J., Pease, R.J., Powell, L.M., Wallis, S.C., Rall, S.C., Innerarity, T.L., Blackhart, B., Taylor, W.H., Marcel, Y., Milne, R. Nature (1986) [Pubmed]
  32. Regulation of glucose transporter messenger RNA in insulin-deficient states. Sivitz, W.I., DeSautel, S.L., Kayano, T., Bell, G.I., Pessin, J.E. Nature (1989) [Pubmed]
  33. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., Offermanns, S. Nat. Med. (2003) [Pubmed]
  34. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Péterfy, M., Phan, J., Xu, P., Reue, K. Nat. Genet. (2001) [Pubmed]
  35. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Agarwal, A.K., Arioglu, E., De Almeida, S., Akkoc, N., Taylor, S.I., Bowcock, A.M., Barnes, R.I., Garg, A. Nat. Genet. (2002) [Pubmed]
  36. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Yamauchi, T., Oike, Y., Kamon, J., Waki, H., Komeda, K., Tsuchida, A., Date, Y., Li, M.X., Miki, H., Akanuma, Y., Nagai, R., Kimura, S., Saheki, T., Nakazato, M., Naitoh, T., Yamamura, K., Kadowaki, T. Nat. Genet. (2002) [Pubmed]
  37. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Tsukiyama-Kohara, K., Poulin, F., Kohara, M., DeMaria, C.T., Cheng, A., Wu, Z., Gingras, A.C., Katsume, A., Elchebly, M., Spiegelman, B.M., Harper, M.E., Tremblay, M.L., Sonenberg, N. Nat. Med. (2001) [Pubmed]
  38. Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse. Rodriguez, A.M., Pisani, D., Dechesne, C.A., Turc-Carel, C., Kurzenne, J.Y., Wdziekonski, B., Villageois, A., Bagnis, C., Breittmayer, J.P., Groux, H., Ailhaud, G., Dani, C. J. Exp. Med. (2005) [Pubmed]
  39. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Hotamisligil, G.S., Arner, P., Caro, J.F., Atkinson, R.L., Spiegelman, B.M. J. Clin. Invest. (1995) [Pubmed]
  40. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. Grunfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A., Friedman, J., Feingold, K.R. J. Clin. Invest. (1996) [Pubmed]
  41. Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. Ahmad, F., Considine, R.V., Goldstein, B.J. J. Clin. Invest. (1995) [Pubmed]
  42. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., Kadowaki, T. J. Clin. Invest. (1998) [Pubmed]
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