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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Adipose Tissue

 
 
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Disease relevance of Adipose Tissue

 

Psychiatry related information on Adipose Tissue

 

High impact information on Adipose Tissue

  • Regulatory elements that control transcription of the PEPCK-C gene in liver, kidney, and adipose tissue have been delineated, and many of the transcription factors that bind to these elements have been identified [10].
  • A pericellular collagenase directs the 3-dimensional development of white adipose tissue [11].
  • The authors show that remodeling of the extracellular matrix by the matrix metalloproteinase MT1-MMP contributes to the three-dimensional development of white adipose tissue in mice [12].
  • We show here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity [13].
  • In particular, DAF-16 activity in the intestine, which is also the animal's adipose tissue, completely restores the longevity of daf-16(-) germline-deficient animals, and increases the lifespans of daf-16(-) insulin/IGF-1-pathway mutants substantially [14].
 

Chemical compound and disease context of Adipose Tissue

 

Biological context of Adipose Tissue

 

Anatomical context of Adipose Tissue

 

Associations of Adipose Tissue with chemical compounds

 

Gene context of Adipose Tissue

  • Uncoupling protein-2 (UCP2) is a recently identified member of the mitochondrial transporter superfamily that is expressed in many tissues, including adipose tissue [21].
  • Consistent with the observed reduction of adipose tissue mass in fld and fld(2J)mice, wild-type Lpin1 mRNA is expressed at high levels in adipose tissue and is induced during differentiation of 3T3-L1 pre-adipocytes [34].
  • AGPAT2 mRNA is highly expressed in adipose tissue [35].
  • Unexpectedly, Crebbp+/- mice showed markedly reduced weight of white adipose tissue (WAT) but not of other tissues [36].
  • Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1 [37].
 

Analytical, diagnostic and therapeutic context of Adipose Tissue

References

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