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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Clonal chromosome aberrations in three sacral chordomas.

Cytogenetic analysis was successful in seven of eight sacral chordomas. Clonal chromosome aberrations were detected in three. One had a t(1;6)(q44;q11) as the sole aberration, one displayed three near-diploid clones that shared del(2)(p21), del(9)(p13), -10, structural rearrangements of 12q13, and add(19)(p13), and the third chordoma had two aberrant cell populations--one hypodiploid with several numerical and structural changes, the other hypertriploid-hypotetraploid with all marker chromosomes in duplicate. Including the present cases, seven cytogenetically aberrant chordomas have been reported. Five have had hypodiploid clones and the most frequent changes have been -3, -4, -10, and -13. No recurrent structural rearrangement has been identified; the only chromosome bands involved more than once are 1q21, 3q11, 5p15, 20q13, and 21q22.[1]

References

  1. Clonal chromosome aberrations in three sacral chordomas. Mertens, F., Kreicbergs, A., Rydholm, A., Willén, H., Carlén, B., Mitelman, F., Mandahl, N. Cancer Genet. Cytogenet. (1994) [Pubmed]
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