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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Decrease in cerebral inositols in rats and humans.

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.[1]


  1. Decrease in cerebral inositols in rats and humans. Moats, R.A., Lien, Y.H., Filippi, D., Ross, B.D. Biochem. J. (1993) [Pubmed]
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