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Moats, R.A. et al.

Decrease in cerebral inositols in rats and humans.

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.[1]

References

Decrease in cerebral inositols in rats and humans. Moats, R.A., Lien, Y.H., Filippi, D., Ross, B.D. Biochem. J. (1993) [Pubmed]

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