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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.

Spicamycin, a nucleoside antibiotic containing fatty acids with a variety of chain lengths (C12-C18), showed potent antitumor activity against human gastric cancer SC-9 and human breast cancer MX-1 in a xenograft model. We have made several semi-synthetic spicamycin analogues (SPMs) which differed in the chain length of the fatty acid moiety, and examined their structure-antitumor activity relationship. The cytotoxic activities of SPMs depended on the chain length of the fatty acid moiety, with dodecanoyl, tetradecanoyl, hexadecanoyl and icosanoyl analogues (SPM VIII, SPM X, SPM XII and SPM XVI) exhibiting the most potent cytotoxic activity against P388 murine leukemia cells. SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs. The antitumor activity of SPM VIII was superior to that of mitomycin C.[1]


  1. Structure-antitumor activity relationship of semi-synthetic spicamycin analogues. Kamishohara, M., Kawai, H., Odagawa, A., Isoe, T., Mochizuki, J., Uchida, T., Hayakawa, Y., Seto, H., Tsuruo, T., Otake, N. J. Antibiot. (1993) [Pubmed]
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