The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Analysis of T cell receptors specific for recognition of class IB antigens.

T cells that recognize a peptide presented by a self-class IA molecule generally use a restricted repertoire of V beta and V alpha receptors. In contrast, alloreactive T cells, which recognize alloantigens that present a wide array of peptides, use a diverse repertoire, particularly in the CDR3 loop. Because the T cell repertoire directed against class IB alloantigens is not known, we examined V-D-J sequences in V beta chains specific for Qa-1 and similar sequences in both V beta and V alpha chains specific for Qa-2. We observed that 14 Qa-1-specific clones use a limited number of V beta segments and 8 of 14 express V beta 8.2 and have a conservation of charged residues in the CDR3 loop, particularly between residues 99 and 101. Thirteen of the 14 clones rearrange to the second J beta cluster and use within this cluster is restricted. Alloreactive anti-Qa-1 T cells can be assigned into three different specificity groups based on a Qa-1 modifying gene, Qdm, as well as Qa-1 epitope expression on Tap-2-deficient RMA-S cells. Receptors from members of each specificity group are more similar in their CDR3 loop to each other than members of the other groups. These data lend support to the Qa-1 class IB Ag presenting a limited number of peptides to T cells or in some manner limiting the development of a diverse alpha beta T cell repertoire. The alpha- and beta-chains from nine alloreactive anti-Qa-2 clones were analyzed. V beta use was limited to use of V beta 7 or a member of the V beta 8 family. Rearrangements were solely to the second J beta cluster. The use of V alpha and J alpha segments were diverse. Although conserved residues or motifs were observed in the CDR3 regions of both the beta- and alpha-chains, the extent of conservation was less than that for anti-Qa-1 receptors. Anti-Qa-2 T cells can be divided into two specificities, Q6 and Q7. No common features were apparent between these groups.[1]


  1. Analysis of T cell receptors specific for recognition of class IB antigens. Lowen, L.C., Aldrich, C.J., Forman, J. J. Immunol. (1993) [Pubmed]
WikiGenes - Universities