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Bergin, P.S. et al.

Failure of 3,4-diaminopyridine to reverse conduction block in inflammatory demyelinating neuropathies.

3,4-Diaminopyridine was administered to 6 patients with inflammatory demyelinating neuropathies in whom partial conduction block was demonstrable. Four had Guillain-BarrÃ© syndrome and 2 had chronic inflammatory demyelinating neuropathy. Nerve conduction studies were performed before the administration of a single oral dose of 3,4-diaminopyridine, and at regular intervals thereafter. Neither resolution of conduction block nor clinical benefit were seen.[1]

References

Failure of 3,4-diaminopyridine to reverse conduction block in inflammatory demyelinating neuropathies. Bergin, P.S., Miller, D.H., Hirsch, N.P., Murray, N.M. Ann. Neurol. (1993) [Pubmed]

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