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MeSH Review

Neural Conduction

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Disease relevance of Neural Conduction


Psychiatry related information on Neural Conduction


High impact information on Neural Conduction


Chemical compound and disease context of Neural Conduction


Biological context of Neural Conduction


Anatomical context of Neural Conduction


Associations of Neural Conduction with chemical compounds


Gene context of Neural Conduction

  • PMP22 duplication caused mainly demyelinating phenotypes with slowed motor nerve conduction velocity (MCV) and demyelinating histopathology, while axonal features were variably present [34].
  • The electrophysiological studies showed that motor nerve conduction velocities in CMTX females, but not males, were heterogeneous between nerves compared with Charcot-Marie-Tooth type 1A (CMT1A) patients and controls [35].
  • OBJECTIVES: To expand our understanding of the characteristics of nerve conduction velocity (NCV) in patients with different MPZ mutations, the authors collected and analysed the NCV values from patients with MPZ mutations [36].
  • Aqp4 knockout mice demonstrated impaired hearing, but normal neural conduction time [37].
  • Mice homozygously deficient for the peripheral myelin protein 22 gene (Pmp22-/-) exhibited increased motor latencies, reduced nerve conduction velocities, and polyphasia of the M-response, which are the typical electrophysiological signs of dysmyelination [38].

Analytical, diagnostic and therapeutic context of Neural Conduction


  1. Rapid improvement in nerve conduction velocity following renal transplantation. Oh, S.J., Clements, R.S., Lee, Y.W., Diethelm, A.G. Ann. Neurol. (1978) [Pubmed]
  2. Acute oxaliplatin-induced peripheral nerve hyperexcitability. Wilson, R.H., Lehky, T., Thomas, R.R., Quinn, M.G., Floeter, M.K., Grem, J.L. J. Clin. Oncol. (2002) [Pubmed]
  3. Coexistence of nerve conduction deficit with increased Na(+)-K(+)-ATPase activity in galactose-fed mice. Implications for polyol pathway and diabetic neuropathy. Calcutt, N.A., Tomlinson, D.R., Biswas, S. Diabetes (1990) [Pubmed]
  4. Autosomal dominant cerebellar ataxia type I. Nerve conduction and evoked potential studies in families with SCA1, SCA2 and SCA3. Abele, M., Bürk, K., Andres, F., Topka, H., Laccone, F., Bösch, S., Brice, A., Cancel, G., Dichgans, J., Klockgether, T. Brain (1997) [Pubmed]
  5. Charcot-Marie-Tooth disease with intermediate motor nerve conduction velocities: characterization of 14 Cx32 mutations in 35 families. Rouger, H., LeGuern, E., Birouk, N., Gouider, R., Tardieu, S., Plassart, E., Gugenheim, M., Vallat, J.M., Louboutin, J.P., Bouche, P., Agid, Y., Brice, A. Hum. Mutat. (1997) [Pubmed]
  6. Hyperalgesia in spontaneous and experimental animal models of diabetic neuropathy. Wuarin-Bierman, L., Zahnd, G.R., Kaufmann, F., Burcklen, L., Adler, J. Diabetologia (1987) [Pubmed]
  7. Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency? Ishibashi, S., Yokota, T., Shiojiri, T., Matunaga, T., Tanaka, H., Nishina, K., Hirota, H., Inaba, A., Yamada, M., Kanda, T., Mizusawa, H. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  8. An open-label, noncomparative study of miglustat in type I Gaucher disease: efficacy and tolerability over 24 months of treatment. Pastores, G.M., Barnett, N.L., Kolodny, E.H. Clinical therapeutics. (2005) [Pubmed]
  9. Neurophysiological findings and serum aluminium in dialysis encephalopathy. Ladurner, G., Wawschinek, O., Pogglitsch, H., Petek, W., Urlesberger, H., Holzer, H. Eur. Neurol. (1982) [Pubmed]
  10. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. Partanen, J., Niskanen, L., Lehtinen, J., Mervaala, E., Siitonen, O., Uusitupa, M. N. Engl. J. Med. (1995) [Pubmed]
  11. Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications. Greene, D.A., Lattimer, S.A., Sima, A.A. N. Engl. J. Med. (1987) [Pubmed]
  12. Aldose reductase inhibition improves nerve conduction velocity in diabetic patients. Judzewitsch, R.G., Jaspan, J.B., Polonsky, K.S., Weinberg, C.R., Halter, J.B., Halar, E., Pfeifer, M.A., Vukadinovic, C., Bernstein, L., Schneider, M., Liang, K.Y., Gabbay, K.H., Rubenstein, A.H., Porte, D. N. Engl. J. Med. (1983) [Pubmed]
  13. Search for the uremic toxin. Decreased motor-nerve conduction velocity and elevated parathyroid hormone in uremia. Avram, M.M., Feinfeld, D.A., Huatuco, A.H. N. Engl. J. Med. (1978) [Pubmed]
  14. Carpal tunnel syndrome. Importance of sensory nerve conduction studies in diagnosis. Hoffman, D.E. JAMA (1975) [Pubmed]
  15. Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats. Cameron, N.E., Cotter, M.A., Dines, K., Love, A. Diabetologia (1992) [Pubmed]
  16. Effect of cilostazol on experimental diabetic neuropathy in the rat. Kihara, M., Schmelzer, J.D., Low, P.A. Diabetologia (1995) [Pubmed]
  17. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Bravenboer, B., Kappelle, A.C., Hamers, F.P., van Buren, T., Erkelens, D.W., Gispen, W.H. Diabetologia (1992) [Pubmed]
  18. Long-term suppression of postprandial hyperglycaemia with acarbose retards the development of neuropathies in the BB/W-rat. Sima, A.A., Chakrabarti, S. Diabetologia (1992) [Pubmed]
  19. Continuous ambulatory peritoneal dialysis: three-year experience at one center. Nolph, K.D., Sorkin, M., Rubin, J., Arfania, D., Prowant, B., Fruto, L., Kennedy, D. Ann. Intern. Med. (1980) [Pubmed]
  20. Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium. Wu, G., Xie, X., Lu, Z.H., Ledeen, R.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  21. Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function. Knipper, M., Bandtlow, C., Gestwa, L., Köpschall, I., Rohbock, K., Wiechers, B., Zenner, H.P., Zimmermann, U. Development (1998) [Pubmed]
  22. Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil. Tomlinson, D.R., Moriarty, R.J., Mayer, J.H. Diabetes (1984) [Pubmed]
  23. Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. Liedtke, W., Leman, E.E., Fyffe, R.E., Raine, C.S., Schubart, U.K. Am. J. Pathol. (2002) [Pubmed]
  24. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Montag, D., Giese, K.P., Bartsch, U., Martini, R., Lang, Y., Blüthmann, H., Karthigasan, J., Kirschner, D.A., Wintergerst, E.S., Nave, K.A. Neuron (1994) [Pubmed]
  25. Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients. Su, Y., Brooks, D.G., Li, L., Lepercq, J., Trofatter, J.A., Ravetch, J.V., Lebo, R.V. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  26. Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene. Smit, J.J., Baas, F., Hoogendijk, J.E., Jansen, G.H., van der Valk, M.A., Schinkel, A.H., Berns, A.J., Acton, D., Nooter, K., Burger, H., Smith, S.J., Borst, P. J. Neurosci. (1996) [Pubmed]
  27. Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation. Yorek, M.A., Wiese, T.J., Davidson, E.P., Dunlap, J.A., Stefani, M.R., Conner, C.E., Lattimer, S.A., Kamijo, M., Greene, D.A., Sima, A.A. Diabetes (1993) [Pubmed]
  28. Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein. Chalk, J.B., McCombe, P.A., Pender, M.P. Brain (1994) [Pubmed]
  29. Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. Greene, D.A., De Jesus, P.V., Winegrad, A.I. J. Clin. Invest. (1975) [Pubmed]
  30. The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. Stevens, M.J., Dananberg, J., Feldman, E.L., Lattimer, S.A., Kamijo, M., Thomas, T.P., Shindo, H., Sima, A.A., Greene, D.A. J. Clin. Invest. (1994) [Pubmed]
  31. Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect. Greene, D.A., Lattimer, S.A. J. Clin. Invest. (1982) [Pubmed]
  32. Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat. Sima, A.A., Prashar, A., Zhang, W.X., Chakrabarti, S., Greene, D.A. J. Clin. Invest. (1990) [Pubmed]
  33. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat. Sima, A.A., Ristic, H., Merry, A., Kamijo, M., Lattimer, S.A., Stevens, M.J., Greene, D.A. J. Clin. Invest. (1996) [Pubmed]
  34. Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients. Hattori, N., Yamamoto, M., Yoshihara, T., Koike, H., Nakagawa, M., Yoshikawa, H., Ohnishi, A., Hayasaka, K., Onodera, O., Baba, M., Yasuda, H., Saito, T., Nakashima, K., Kira, J., Kaji, R., Oka, N., Sobue, G. Brain (2003) [Pubmed]
  35. Clinical, electrophysiological and molecular genetic characteristics of 93 patients with X-linked Charcot-Marie-Tooth disease. Dubourg, O., Tardieu, S., Birouk, N., Gouider, R., Léger, J.M., Maisonobe, T., Brice, A., Bouche, P., LeGuern, E. Brain (2001) [Pubmed]
  36. Median nerve motor conduction velocity is concordant with myelin protein zero gene mutation. Lee, Y.C., Soong, B.W., Liu, Y.T., Lin, K.P., Kao, K.P., Wu, Z.A. J. Neurol. (2005) [Pubmed]
  37. Aquaporin 4 expression in the mammalian inner ear and its role in hearing. Mhatre, A.N., Stern, R.E., Li, J., Lalwani, A.K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  38. Nerve conduction abnormalities and neuromyotonia in genetically engineered mouse models of human hereditary neuropathies. Zielasek, J., Toyka, K.V. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  39. Action of sorbinil in diabetic peripheral nerve. Relationship of polyol (sorbitol) pathway inhibition to a myo-inositol-mediated defect in sodium-potassium ATPase activity. Greene, D.A., Lattimer, S.A. Diabetes (1984) [Pubmed]
  40. Nerve conduction velocity in man: influence of glucose, somatostatin and electrolytes. Orskov, L., Worm, M., Schmitz, O., Mengel, A., Sidenius, P. Diabetologia (1994) [Pubmed]
  41. Vitamin B12 levels and nerve conduction velocities in patients undergoing maintenance hemodialysis. Rostand, S.G. Am. J. Clin. Nutr. (1976) [Pubmed]
  42. Clinical and morphologic features of a myopathy associated with a point mutation in the mitochondrial tRNA(Pro) gene. Ionasescu, V.V., Hart, M., DiMauro, S., Moraes, C.T. Neurology (1994) [Pubmed]
  43. Complications: neuropathy, pathogenetic considerations. Greene, D.A., Sima, A.A., Stevens, M.J., Feldman, E.L., Lattimer, S.A. Diabetes Care (1992) [Pubmed]
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