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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region.

A cDNA encoding bovine procathepsin B was isolated. The deduced amino acid sequence revealed that a stop (TAG) codon, instead of a Trp-257 codon (TGG), generates in bovine a cathepsin B precursor four amino acids shorter than in other species. Because micro-heterogeneities were previously reported in the cathepsin B primary structure, sequence polymorphism in the protein coding region was then investigated by PCR sequencing of genomic fragments and RNase protection assays. Experiments performed with 12-15 animals of three breeds did not reveal any difference with our cDNA sequence. We conclude that sequence polymorphism in bovine cathepsin B is a rare event, and can only result from the expression of different alleles of a unique gene.[1]

References

  1. Nucleotide sequence of bovine preprocathepsin B. A study of polymorphism in the protein coding region. Mordier, S., Béchet, D., Roux, M.P., Obled, A., Ferrara, M. Biochim. Biophys. Acta (1993) [Pubmed]
 
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