- The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Ip, N.Y., McClain, J., Barrezueta, N.X., Aldrich, T.H., Pan, L., Li, Y., Wiegand, S.J., Friedman, B., Davis, S., Yancopoulos, G.D. Neuron (1993)