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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Failure of papaverine to alter L-dopa-influenced GH and PRL secretion.

Papaverine, 150 mg BID for 2 weeks, a dose which produced marked clinical impairment in Parkinsonian patients taking L-Dopa, failed to alter L-Dopa-stimulated GH secretion or L-Dopa inhibited PRL secretion in 6 normal volunteers. Failure to demonstrate an inhibitory effect of papaverine on dopaminergic hypothalamic-pituitary systems, despite its inhibition of striatal dopaminergic pathways, may imply qualitative or quantitative functional differences between hypothalamic and striatal dopaminergic systems.[1]

References

  1. Failure of papaverine to alter L-dopa-influenced GH and PRL secretion. Cooper, D.S., Jacobs, L.S. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
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