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Chemical Compound Review

Cerespan     1-[(3,4- dimethoxyphenyl)methyl]- 6,7...

Synonyms: Ceraspan, Dispamil, Drapavel, Forpavin, Mesotina, ...
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Psychiatry related information on PAPAVERINE HYDROCHLORIDE

  • When illicit heroin was abused, additionally to further general markers (COD, C6G) specific markers for non-prescription heroin abuse (AC, NOS, PAP) were found [2].

High impact information on PAPAVERINE HYDROCHLORIDE

  • The capacity of the coronary system to increase blood flow in response to acetylcholine expressed as relative proportion of the maximal papaverin response was 52.5 +/- 18.2% in the normal control patients but only 33.6 +/- 23.6% in the CAD patients (p less than 0.025 versus normals) [3].
  • However, after inhibition of smooth muscle tone (using 10(-4) M papaverin), a significant change in flow resistance was observed in a RBC suspension with a 97% increase of ESR [4].
  • IL-1 alpha and TNF induced rapid dose-dependent inhibition of stomach motility, with maximal relaxation equal to that induced by 100 microM papaverin, and respective EC50s of 20 and 450 pg/ml [5].
  • Antiepileptic actions of the organic calcium antagonists flunarizine (cinnarizine derivate) and verapamil (papaverin derivat) on pentylenetetrazol-induced epileptic bioelectric activity were tested in CA3 neurones of hippocampal slices [6].
  • In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases [7].


  • Infusion of papaverin (5 x 10(-5) M) following an identical protocol caused a similar vasodilation as SIN-IC, but did not reduce infarct size in five additional dox experiments.(ABSTRACT TRUNCATED AT 250 WORDS)[8]
  • 172 patients with impotence symptoms were investigated by SBBBV-test, orthostatic blood pressure, Doppler examination of the superficial and deep penile arteries, penile-brachial index, visual sexual stimulation, papaverin test, and measurement of bulbocavernous reflex latency time [9].



Associations of PAPAVERINE HYDROCHLORIDE with other chemical compounds



  • We have studied the effect of a hypotensive dose of atrial natriuretic peptide (n = 16), 8-Br-cGMP (n = 5), and papaverin (n = 7) on plasma ET-1 in anesthetized dogs [17].
  • Visual sexual stimulation and papaverin test correlated well with each other, and so did papaverin test and PBI in cases of arterial insufficiency [9].

Analytical, diagnostic and therapeutic context of PAPAVERINE HYDROCHLORIDE

  • When vasospasm is present, papaverin infusion or angioplasty may be used by the endovascular approach as well [18].
  • It was demonstrated that the increase of basal blood flow through left pancreatic segments, induced by intra-arterial injection of papaverin, remained unchanged during 6 months after duct-obliteration [19].


  1. Protective effect of mild hypothermia on symptomatic vasospasm: a preliminary report. Nagao, S., Irie, K., Kawai, N., Kunishio, K., Ogawa, T., Nakamura, T., Okauchi, M. Acta Neurochir. Suppl. (2000) [Pubmed]
  2. Validated assay for the determination of markers of illicit heroin in urine samples for the control of patients in a heroin prescription program. Musshoff, F., Trafkowski, J., Madea, B. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  3. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Zeiher, A.M., Drexler, H., Wollschläger, H., Just, H. Circulation (1991) [Pubmed]
  4. Graded alterations of RBC aggregation influence in vivo blood flow resistance. Yalcin, O., Uyuklu, M., Armstrong, J.K., Meiselman, H.J., Baskurt, O.K. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  5. Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro. Montuschi, P., Preziosi, P., Navarra, P. Eur. J. Pharmacol. (1993) [Pubmed]
  6. Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil. Bingmann, D., Speckmann, E.J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1989) [Pubmed]
  7. Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats. Bingmann, D., Speckmann, E.J., Baker, R.E., Ruijter, J., de Jong, B.M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1988) [Pubmed]
  8. Intracoronary SIN-1C during reperfusion reduces infarct size in dog. Schlack, W., Uebing, A., Schäfer, M., Bier, F., Grunert, S., Ebel, D., Piper, H.M., Thämer, V. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  9. The value of basic investigations in the diagnosis of impotence. Ruutu, M.L., Virtanen, J.M., Lindström, B.L., Alfthan, O.S. Scandinavian journal of urology and nephrology. (1987) [Pubmed]
  10. Papaverine-induced inhibition of electrical and mechanical activity and calcium movements of rat ileal smooth muscle. Huddart, H., Saad, K.H. J. Exp. Biol. (1980) [Pubmed]
  11. Vasorelaxant effect of iloprost on isolated human internal mammary artery. Serbest, M.O., Soner, B.C., Sariosmanoglu, O.N., Kalkan, S., Guven, H., Ugurlu, B., Hazan, E., Oto, O. Fundamental & clinical pharmacology (2007) [Pubmed]
  12. Comments on the article "Intra-arterial injection of papaverin in the decision of balloon dilatation of the iliac arteries" by P.T. Peene et al. Janevski, B.K., Breslau, P.J., Jörning, P.J. RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. (1990) [Pubmed]
  13. Vascular smooth muscle reactivity and endothelium derived relaxing factor in experimental obstructive jaundice. Utkan, T., Sarioglu, Y., Utkan, N.Z., Gönüllü, N.N., Yildirim, M.K. Arch. Physiol. Biochem. (1996) [Pubmed]
  14. Transthoracic Doppler echocardiographic assessment of left anterior descending coronary artery and intramyocardial small coronary artery flow in patients with hypertrophic cardiomyopathy. Minagoe, S. Journal of cardiology. (2001) [Pubmed]
  15. Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: sildenafil and papaverin generate inhibition. Adolfsson, P.I., Ahlstrand, C., Varenhorst, E., Svensson, S.P. Prostate (2002) [Pubmed]
  16. Electrical activity from rat corpora is affected by pharmacological but not mechanical intracorporal manipulation. Vardi, Y., Bernabe, J., Dashkovsky, A., Tarchnishvili, A., Rogowski, Z., Giuliano, F., Yarnitsky, D. Pflugers Arch. (1998) [Pubmed]
  17. Plasma endothelin-1 response to acute hypotension induced by vasodilating agents. Cernacek, P., Stewart, D.J., Levy, M. Can. J. Physiol. Pharmacol. (1994) [Pubmed]
  18. Endovascular treatment of ruptured intracranial aneurysms. Pruvo, J.P., Leclerc, X., Ares, G.S., Lejeune, J.P., Leys, D. J. Neurol. (1999) [Pubmed]
  19. The persisting capability for vasodilatation in duct-occluded canine pancreatic segments. van Schilfgaarde, R., Gooszen, H.G. Horm. Metab. Res. Suppl. (1983) [Pubmed]
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