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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.

Phosphorylase kinase (PHK) is a regulatory enzyme of the glycogenolytic pathway composed of a complex of four subunits. We recently mapped the muscle alpha-subunit gene (Phka) to the mouse X chromosome in a region syntenic with the proximal long arm of the human X chromosome and containing the human homologue of this gene, PHKA. We now report the mapping of the liver alpha-subunit gene to the telomeric end of the mouse X chromosome. This mapping position would suggest a location for the human liver alpha-subunit gene on the proximal short arm of the X chromosome, a region recently implicated in X-linked liver glycogenosis (XLG).[1]

References

  1. Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome. Geng, Y., Derry, J.M., Hendrickx, J., Coucke, P., Willems, P.R., Barnard, P.J. Genomics (1993) [Pubmed]
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