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Moran, E.

DNA tumor virus transforming proteins and the cell cycle.

Studies using the transforming proteins of the small DNA tumor viruses point to the role of the E2F cellular transcription factor in regulating cell cycle specific gene expression. The evidence derived suggests that E2F is controlled by the retinoblastoma gene product and related proteins, including their associated cyclins. Studies using DNA tumor virus products further suggest the existence of additional pathways of cell-cycle activation.[1]

References

DNA tumor virus transforming proteins and the cell cycle. Moran, E. Curr. Opin. Genet. Dev. (1993) [Pubmed]

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