Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii.
The sequences of the rRNA genes of Pneumocystis carinii from rat and human sources demonstrate three distinct genotypes based on the group I introns present in these genes. One rat isolate ( Pc1) contains such introns in its 16S and 26S rRNA genes, while another rat isolate ( Pc2) and a human isolate ( Pc3) only contain an intron in the 26S rRNA gene. The four introns all catalyze their own excision from RNA transcripts, and this reaction is inhibited by the anti-pneumocystis drug pentamidine and its analogues. Although they differ in sequence, they are more similar to one another than to group I introns found in other eukaryotic microbes.[1]References
- Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii. Liu, Y., Leibowitz, M.J. Nucleic Acids Res. (1993) [Pubmed]
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