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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fibrodysplasia ossificans progressiva and synovial chondromatosis.

Two cases of an unusual association-fibrodysplasia ossificans progressiva and synovial chondromatosis-in non-related children are presented. This association does not seem coincidental and raises several questions about the pathogenesis. A genetic hypothesis related to G proteins is proposed. This is supported by the fact that such abnormalities have been demonstrated in pseudohypoparathyroidism and fibrous dysplasia; these diseases can also be associated with fibrodysplasia ossificans progressiva.[1]


  1. Fibrodysplasia ossificans progressiva and synovial chondromatosis. Kalifa, G., Adamsbaum, C., Job-Deslande, C., Dubousset, J. Pediatric radiology. (1993) [Pubmed]
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