Disease relevance of Chondromatosis, Synovial

• Nine such cases of synovial diseases, including synovial osteochondromatosis, pigmented villonodular synovitis, rheumatoid arthritis, and amyloidosis, that demonstrate this radiographic finding are presented [1].
• Telomerase activity in synovial tissues was detected in 28 of 47 (59.6%) patients with RA, including monoarticular-type RA, but in none of those with other joint diseases except one case each of synovial chondromatosis and OA [2].
• Such disorders include gout, Milwaukee shoulder, rapidly destructive articular disease, amyloid arthropathy, hemophilic arthropathy, primary synovial osteochondromatosis, pigmented villonodular synovitis, neuropathic arthropathy, and foreign-body synovitis [3].
• Arthroscopic intervention has been reported in synovial chondromatosis and osteochondromatosis, pigmented villonodular synovitis, inflammatory arthropathies including rheumatoid arthritis, and acute septic arthritis [4].
• Other possible diagnoses include osteoarthritis, rheumatoid arthritis, gout, trauma and chronic infection, and unless enchondral ossification of loose bodies is seen the diagnosis of synovial chondromatosis may not be made preoperatively [5].

High impact information on Chondromatosis, Synovial

• Octacalcium phosphate (OCP) was found in all samples except that from a patient with synovial chondromatosis which contained tricalcium phosphate (TCP) [6].
• Eighty-five per cent of Gli3 mutant mice developed synovial chondromatosis at 18 months of age, compared with 30% of wild-type littermates (p < 0.05) [7].
• Three of the ten Gli3 mutant mice treated with triparanol, which blocks hedgehog signalling upstream of the Gli transcription factors, developed synovial chondromatosis, compared with eight of ten control mice [7].
• Because dysregulation of hedgehog signalling is a feature of several benign cartilaginous tumours, expression of the hedgehog target genes PTC1 and GLI1 was examined in this study in samples from human synovial chondromatosis [7].
• Despite these results, there was no Ki-67 positive staining in synovial chondromatosis, which tends to suggest that the demonstrated expression of C-erb B-2 is not related to proliferative activity [8].

Chemical compound and disease context of Chondromatosis, Synovial

• Uptake of technetium-99m MDP in synovial osteochondromatosis. Another cause of nonosseous activity on bone scan [9].
• STUDY DESIGN: Eight subjects with synovial chondromatosis were examined with axial and coronal CT scans [10].
• Markedly increased periarticular Tc-99m diphosphonate uptake around the knee is described in a patient found to have synovial chondromatosis [11].
• Uptake of pentavalent technetium-99m dimercaptosuccinic acid in idiopathic synovial chondromatosis [12].
• We report a case of recurrent M. marinum infection involving the flexor tendons within the carpal tunnel in which the rice bodies were mistaken for synovial chondromatosis on MR images [13].

Anatomical context of Chondromatosis, Synovial

• Elevated levels of FGF 9, its specific ligand, have been found in synovial fluids of patients with synovial chondromatosis [14].
• The expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 in chondrocytes in synovial chondromatosis of the temporomandibular joint. report of two cases [15].

Gene context of Chondromatosis, Synovial

• Synovial chondromatosis: the possible role of FGF 9 and FGF receptor 3 in its pathology [14].
• Other cartilaginous lesions (including loose bodies of primary synovial chondromatosis) were negative for amyloid and did not contain highly sulphated glycosaminoglycans [16].
• Fibrodysplasia ossificans progressiva and synovial chondromatosis [17].

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