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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.

A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition of [3H]quinuclidinyl benzilate binding) and in vivo (reversal of scopolamine-induced dementia) as potential agents for the treatment of Alzheimer's disease. Compounds displaying significant activity were more broadly evaluated, which revealed the presence of a desirable adrenergic component of activity. The synthesis and structure-activity relationships for this series is presented, along with the biological profiles of selected compounds.[1]

References

  1. Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease. Davis, L., Olsen, G.E., Klein, J.T., Kapples, K.J., Huger, F.P., Smith, C.P., Petko, W.W., Cornfeldt, M., Effland, R.C. J. Med. Chem. (1996) [Pubmed]
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