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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Modulation of K+ channel currents by serum amineoxidase in neurons.

The influence of bovine serum amineoxidase ( SAO), a circulating copper-enzyme, on neuronal K+ channels is described. Bovine SAO enhanced K+ channel currents in N1E-115 neuroblastoma cells in a time-dependent manner. Unlike ceruloplasmin (another copper-protein, shown as depolarizing factor in neurons), SAO had no effect on resting potential of neurons. However, pretreatment of cells with SAO inhibited ceruloplasmin-induced membrane depolarization. Although ceruloplasmin alone inhibited K+ channel currents, it further enhanced K+ channel currents in the presence of SAO. Therefore, SAO may be another endogenous modulator of neuronal K+ channels with effect and mechanisms different from those of ceruloplasmin.[1]


  1. Modulation of K+ channel currents by serum amineoxidase in neurons. Wu, L., Mateescu, M.A., Wang, X.T., Mondovi, B., Wang, R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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