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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Essential flexibility in the T-cell recognition of antigen.

alpha beta T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.[1]

References

  1. Essential flexibility in the T-cell recognition of antigen. Kersh, G.J., Allen, P.M. Nature (1996) [Pubmed]
 
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