Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Avery, E.L. et al.

The detection of pollutant impact in marine environments: condition index, oxidative DNA damage, and their associations with metal bioaccumulation in the Sydney rock oyster Saccostrea commercialis.

Specimens of the Sydney rock oyster Saccostrea commercialis were deployed for a 3-month period at control and sewage disturbed marine locations in the Hunter Region, New South Wales, Australia. The DNA damage product,8-hydroxyguanine, was measured by GC/MS- SIM from chromatin extracts of the gill tissues of oysters to assess oxidative damage. The levels ranged from 11.5 to 18.8 modified bases per 10(7) guanine bases. Although the condition indices were significantly different between the Redhead control site (178.3+/-3. 6) and the Burwood sewage disturbed location (140.4+/-4.4), no significant differences in 8-hydroxyguanine concentrations were detected between the sites, and the concentration of 8-hydroxyguanine was not correlated to condition index. However, levels of the DNA base modification were correlated with the concentrations of bioaccumulated lead (r=0.84, P=0.036). This association provides in vivo evidence that the bioaccumulation of lead results in oxidative damage to DNA. An additional control and sewage disturbed site were included to investigate the relationship between heavy metal bioaccumulation and the condition index of deployed oysters. After the 3-month deployment period, the condition index was negatively correlated to concentrations of bioaccumulated mercury (r=-0.80, P<0.001), cobalt (r=-0.65, P<0.01), and nickel (r=-0.69, P<0.01), suggesting a strong negative influence of these metals at relatively low concentrations on the physiological condition of the oysters.[1]

References

The detection of pollutant impact in marine environments: condition index, oxidative DNA damage, and their associations with metal bioaccumulation in the Sydney rock oyster Saccostrea commercialis. Avery, E.L., Dunstan, R.H., Nell, J.A. Arch. Environ. Contam. Toxicol. (1996) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.