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Chemical Compound Review

SureCN22144     2-amino-7,9-dihydro-3H- purine-6,8-dione

Synonyms: SureCN42760, SureCN42761, AG-G-05609, SureCN6481197, SureCN7168821, ...
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Disease relevance of NSC22720


High impact information on NSC22720


Chemical compound and disease context of NSC22720


Biological context of NSC22720


Anatomical context of NSC22720


Associations of NSC22720 with other chemical compounds


Gene context of NSC22720

  • Using the method we developed, it was demonstrated that the number of oh(8)G (indicated by 8-hydroxyguanine glycosylase (OGG1) sensitive sites) in GAPDH was almost not changed in H. pylori-infected tissue but in IGFIIR, it increased significantly [23].
  • Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue [24].
  • We previously reported that the CSB protein is involved in cellular repair of 8-hydroxyguanine, an abundant lesion in oxidatively damaged DNA and that the putative helicase motif V/VI of the CSB may play a role in this process [25].
  • Biallelic germ-line variants of the 8-hydroxyguanine repair gene MYH have been associated with multiple colorectal adenomas that display somatic G:C-->T:A transversions in APC [26].
  • Increasing SOD1 levels by gene transfection in NT-2 and SK-N-MC cell lines also led to a rise in glutathione peroxidase activity, but this was nevertheless accompanied by decreased proliferation rates, increased lipid peroxidation and protein carbonyls, and a trend to a rise in 8-hydroxyguanine and protein-bound 3-nitrotyrosine [27].

Analytical, diagnostic and therapeutic context of NSC22720


  1. Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. Bessho, T., Roy, R., Yamamoto, K., Kasai, H., Nishimura, S., Tano, K., Mitra, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. Mambo, E., Nyaga, S.G., Bohr, V.A., Evans, M.K. Cancer Res. (2002) [Pubmed]
  3. The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA. Tuo, J., Müftüoglu, M., Chen, C., Jaruga, P., Selzer, R.R., Brosh, R.M., Rodriguez, H., Dizdaroglu, M., Bohr, V.A. J. Biol. Chem. (2001) [Pubmed]
  4. Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli. Wood, M.L., Esteve, A., Morningstar, M.L., Kuziemko, G.M., Essigmann, J.M. Nucleic Acids Res. (1992) [Pubmed]
  5. Radiation sensitivity depends on OGG1 activity status in human leukemia cell lines. Hyun, J.W., Cheon, G.J., Kim, H.S., Lee, Y.S., Choi, E.Y., Yoon, B.H., Kim, J.S., Chung, M.H. Free Radic. Biol. Med. (2002) [Pubmed]
  6. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Minowa, O., Arai, T., Hirano, M., Monden, Y., Nakai, S., Fukuda, M., Itoh, M., Takano, H., Hippou, Y., Aburatani, H., Masumura, K., Nohmi, T., Nishimura, S., Noda, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Free radical adducts induce alterations in DNA cytosine methylation. Weitzman, S.A., Turk, P.W., Milkowski, D.H., Kozlowski, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to toxic chemicals. Malins, D.C., Gunselman, S.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Yoneyama, T., Wilson, L.M., Hatakeyama, K. Arch. Biochem. Biophys. (2001) [Pubmed]
  10. Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid. Rodriguez, H., Jurado, J., Laval, J., Dizdaroglu, M. Nucleic Acids Res. (2000) [Pubmed]
  11. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Tchou, J., Kasai, H., Shibutani, S., Chung, M.H., Laval, J., Grollman, A.P., Nishimura, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking. Asami, S., Hirano, T., Yamaguchi, R., Tomioka, Y., Itoh, H., Kasai, H. Cancer Res. (1996) [Pubmed]
  13. Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Arai, T., Kelly, V.P., Komoro, K., Minowa, O., Noda, T., Nishimura, S. Cancer Res. (2003) [Pubmed]
  14. Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Russo, M.T., De Luca, G., Degan, P., Parlanti, E., Dogliotti, E., Barnes, D.E., Lindahl, T., Yang, H., Miller, J.H., Bignami, M. Cancer Res. (2004) [Pubmed]
  15. Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet. Nakae, D., Kotake, Y., Kishida, H., Hensley, K.L., Denda, A., Kobayashi, Y., Kitayama, W., Tsujiuchi, T., Sang, H., Stewart, C.A., Tabatabaie, T., Floyd, R.A., Konishi, Y. Cancer Res. (1998) [Pubmed]
  16. Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Park, K.S., Kim, J.H., Kim, M.S., Kim, J.M., Kim, S.K., Choi, J.Y., Chung, M.H., Han, B., Kim, S.Y., Lee, H.K. Diabetes (2001) [Pubmed]
  17. Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells. Bessho, T., Tano, K., Kasai, H., Ohtsuka, E., Nishimura, S. J. Biol. Chem. (1993) [Pubmed]
  18. Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals. Karahalil, B., Girard, P.M., Boiteux, S., Dizdaroglu, M. Nucleic Acids Res. (1998) [Pubmed]
  19. Substrate specificities of the ntg1 and ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical. Sentürker, S., Auffret van der Kemp, P., You, H.J., Doetsch, P.W., Dizdaroglu, M., Boiteux, S. Nucleic Acids Res. (1998) [Pubmed]
  20. Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Lee, M., Hyun, D.H., Marshall, K.A., Ellerby, L.M., Bredesen, D.E., Jenner, P., Halliwell, B. Free Radic. Biol. Med. (2001) [Pubmed]
  21. Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis. Lim, Y.K., Jenner, A., Ali, A.B., Wang, Y., Hsu, S.I., Chong, S.M., Baumman, H., Halliwell, B., Lim, S.K. Kidney Int. (2000) [Pubmed]
  22. DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. Turk, P.W., Laayoun, A., Smith, S.S., Weitzman, S.A. Carcinogenesis (1995) [Pubmed]
  23. Measurement of oxidative damage at individual gene levels by quantitative PCR using 8-hydroxyguanine glycosylase (OGG1). Choi, J., Kim, D.Y., Hyun, J.W., Yoon, S.H., Choi, E.M., Hahm, K.B., Rhee, K.H., Chung, M.H. Mutat. Res. (2003) [Pubmed]
  24. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., Asano, M. Cancer Res. (1997) [Pubmed]
  25. The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. Tuo, J., Jaruga, P., Rodriguez, H., Dizdaroglu, M., Bohr, V.A. J. Biol. Chem. (2002) [Pubmed]
  26. Role of inherited defects of MYH in the development of sporadic colorectal cancer. Kambara, T., Whitehall, V.L., Spring, K.J., Barker, M.A., Arnold, S., Wynter, C.V., Matsubara, N., Tanaka, N., Young, J.P., Leggett, B.A., Jass, J.R. Genes Chromosomes Cancer (2004) [Pubmed]
  27. Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis. Lee, M., Hyun, D., Jenner, P., Halliwell, B. J. Neurochem. (2001) [Pubmed]
  28. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Kamiya, H., Miura, K., Ishikawa, H., Inoue, H., Nishimura, S., Ohtsuka, E. Cancer Res. (1992) [Pubmed]
  29. Relations between clusters of oxidatively damaged nucleotides and active or open nucleosomes in the rat Nth 1 gene. Nomoto, M., Yamaguchi, R., Kohno, K., Kasai, H. Oncogene (2002) [Pubmed]
  30. Endonuclease-sensitive DNA modifications induced by acetone and acetophenone as photosensitizers. Epe, B., Henzl, H., Adam, W., Saha-Möller, C.R. Nucleic Acids Res. (1993) [Pubmed]
  31. Oh8dG induces G1 arrest in a human acute leukemia cell line by upregulating P21 and blocking the RAS to ERK signaling pathway. Hyun, J.W., Yoon, S.H., Yu, Y., Han, C.S., Park, J.S., Kim, H.S., Lee, S.J., Lee, Y.S., You, H.J., Chung, M.H. Int. J. Cancer (2006) [Pubmed]
  32. The level of 8-hydroxyguanine, a possible repair product of oxidative DNA damage, is higher in urine of cancer patients than in control subjects. Rozalski, R., Gackowski, D., Roszkowski, K., Foksinski, M., Olinski, R. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
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