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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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alpha-Tocopherylquinone: effect on blood pressure in normotensive volunteers and its plasma concentrations in men and dogs.

Three normotensive volunteers were given oral doses of alpha-tocopherylquinone. Blood pressure and its plasma concentrations were measured before and within 6 hours after taking this drug. Two dogs were given alpha-tocopherylquinone orally and after 3 days intravenously. Plasma concentrations were measured after each administration. Our result showed that this drug did not affect the blood pressure of normotensive individuals, and only small concentrations of alpha-tocopherylquinone were detected in plasma. In dogs, oral doses gave higher plasma levels than intravenous administration.[1]

References

  1. alpha-Tocopherylquinone: effect on blood pressure in normotensive volunteers and its plasma concentrations in men and dogs. Lamid, S., Crout, J.R. International journal of clinical pharmacology and biopharmacy. (1977) [Pubmed]
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