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van der Reijden, W.A. et al.

van der Reijden, van der Kwaak, Veerman, Nieuw Amerongen,

Analysis of the concentration and output of whole salivary constituents in patients with SjÃ¶gren's syndrome.

In SjÃ¶gren's syndrome, salivary glands are affected, resulting in a diminished salivary flow. In the present study, the protein composition, sialic acid content and the amounts of calcium and phosphate of stimulated whole saliva from 43 patients with SjÃ¶gren's syndrome, were compared with those of control saliva samples from 17 healthy subjects. The absolute concentrations of albumin, cystatin C, cystatin S, total IgA and total protein, but not amylase, were increased significantly in both primary and secondary SjÃ¶gren's syndrome. The output/min of total protein, albumin, amylase, and IgA was, however, decreased in SjÃ¶gren patients. These results suggest that the diminished output of salivary defence factors, rather than their absolute concentrations, may be related to the oral health problems seen in SjÃ¶gren's syndrome patients.[1]

References

Analysis of the concentration and output of whole salivary constituents in patients with Sjögren's syndrome. van der Reijden, W.A., van der Kwaak, J.S., Veerman, E.C., Nieuw Amerongen, A.V. Eur. J. Oral Sci. (1996) [Pubmed]

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