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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Progesterone treatment in chylothorax associated with pulmonary tuberous sclerosis.

We report the case of a young woman with tuberous sclerosis who developed a chylous pleural effusion after several invasive procedures for treatment of recurring pneumothoraces. Oophorectomy was rejected by the patient and progesterone therapy initiated. Medroxyprogesterone acetate administration led to a complete disappearance of the chylothorax in 8 months. The patient was kept on therapy, and no recurrence of pleural effusion has been observed up to the present (22 months follow-up). However, a progressive deterioration in pulmonary function was observed, with a significant decrease in pulmonary transfer factor and increase in airway obstruction. In conclusion, this report demonstrates an objective benefit of progesterone therapy on chylous effusion associated with pulmonary tuberous sclerosis.[1]

References

  1. Progesterone treatment in chylothorax associated with pulmonary tuberous sclerosis. Jounieaux, V., Druelle, S., Mayeux, I., Grimault, E., Charet, J.C. Eur. Respir. J. (1996) [Pubmed]
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