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Puzo, G. et al.

Incorporation of oxygen-18 into nucleosides and bases.

Extensive incorporation of oxygen-18 at position O4 of the pyrimidine nucleus results from exchange between H218O and nucleosides or bases in 1N HC1 at 100 degrees. The reaction is hindered by substitution at C-5 with the greatest effect shown in pseudouridine (R = ribosy1) and the least in uridine (R = H). Maximum incorporation in the latter compound was 94%, and in uricil was 98%. The method is experimentally simple and the incorporation is readily monitored by mass spectrometry.[1]

References

Incorporation of oxygen-18 into nucleosides and bases. Puzo, G., Schram, K.H., McCloskey, J.A. Nucleic Acids Res. (1977) [Pubmed]

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