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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of pentachlorophenol on calcium accumulation in barnacle muscle cells.

1. The effect of extracellularly applied pentachlorophenol (PCP) was studied on the membrane potential (Vm) and Ca2+ uptake in isolated single skeletal muscle cells of Balanus nubilus. 2. When compared with the controls, 0.1 mM PCP induced a significant (P < 0.05) increase in Ca2+ uptake accompanied by membrane depolarization (9 mV at 45 min incubation). This depolarization was reduced by 11% of extracellular Ca2+ (Cao2+) was replaced by Tris+ and by 50% if extracellular Na+ was also replaced by Tris+. 3. The Ca2+ channel blocker, verapamil (0.1 mM), completely inhibited the PCP-induced Ca2+ uptake as well as the membrane depolarization either in the absence or presence of Cao2+. Experiments on voltage-clamped cells show that the PCP-induced Ca2+ uptake was independent of the PCP-induced depolarization. 4. The results indicate that PCP induces activation of a verapamil-sensitive Ca2+ influx pathway (presumably L-type Ca2+ channels) independent of Vm. The permeation of Ca2+, Na+ and Tris+ through this pathway produces membrane depolarization in the following order of effectiveness: Ca2+ > Na+ > Tris+.[1]

References

  1. Effect of pentachlorophenol on calcium accumulation in barnacle muscle cells. Nwoga, J.C., Sniffen, J.C., Peña-Rasgado, C., Kimler, V.A., Rasgado-Flores, H. J. Physiol. (Lond.) (1996) [Pubmed]
 
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