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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Primary cardiac gastrinoma causing Zollinger-Ellison syndrome.

Primary cardiac tumors are rare, and there are no reports of patients with a functional gastroenteropancreatic tumor syndrome caused by such a tumor. This case report describes a patient with a cardiac gastrinoma causing Zollinger-Ellison syndrome. Evidence is presented that this tumor represents a primary cardiac tumor. The exact identification of this gastrinoma in an extra-abdominal site was facilitated by the use of [111In-DTPA-DPhe1]octreotide scanning for somatostatin receptors, which these tumors characteristically possess in high numbers. The recent availability of this novel localization method may facilitate identification of extra-abdominal sites in an increasing proportion of patients with gastrinomas and related neuroendocrine functional tumors in which no intra-abdominal primary tumor is currently found.[1]


  1. Primary cardiac gastrinoma causing Zollinger-Ellison syndrome. Gibril, F., Curtis, L.T., Termanini, B., Fritsch, M.K., Lubensky, I.A., Doppman, J.L., Jensen, R.T. Gastroenterology (1997) [Pubmed]
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