Gene Review:
SST - somatostatin
Homo sapiens
Synonyms:
Growth hormone release-inhibiting factor, SMST, Somatostatin
Bronowicki,
Oberhuber,
Besseghir,
Coggeshall,
Hillon,
Silvain,
Crotta,
Casnici,
Wappenschmidt,
Mielke,
Garnier,
Raderer,
Patel,
Ribard,
Pekala,
Veldhuis,
Bugert,
Grigorakis,
Shen,
Botta-Fridlund,
Fiebiger,
Hejna,
Marelli,
Wagner,
Försti,
Morisset,
Iranmanesh,
Schmutzler,
Scheithauer,
Masliah,
Franco,
Hemminki,
Mastrotto,
Pamula,
Carlton,
Nele Garbrecht,
Martin Anlauf,
Anja Schmitt,
Tobias Henopp,
Bence Sipos,
Andreas Raffel,
Claus F. Eisenberger,
Wolfram T. Knoefel,
Marianne Pavel,
Christian Fottner,
Thomas J. Musholt,
Anja Rinke,
Rudolf Arnold,
Uta Berndt,
Ursula Plöckinger,
Bertram Wiedenmann,
Holger Moch,
Philipp U. Heitz,
Paul Komminoth,
Aurel Perren,
Günter Klöppel,
Kurtaran,
Grzybowska,
Szostak-Talbodec,
Burwinkel,
Calès,
Kumar,
Davidson,
Bowers,
Du,
Schmidinger,
Bernard,
Zhou,
Lebrec,
Carpenter,
Goodyer,
Bourassa,
Lainé,
Lattuada,
Klaes,
Miles,
Butkiewicz,
Lessard,
Weinlaender,
Guilloteau,
Rome,
Raderer,
Srikant,
Schmid,
- High expression of somatostatin receptors and messenger ribonucleic acid for its receptor subtypes in organ-confined and locally advanced human prostate cancers. Halmos, G., Schally, A.V., Sun, B., Davis, R., Bostwick, D.G., Plonowski, A. J. Clin. Endocrinol. Metab. (2000)
- Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238. Kiaris, H., Schally, A.V., Nagy, A., Sun, B., Szepeshazi, K., Halmos, G. Clin. Cancer Res. (2000)
- Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. Wagner, K., Hemminki, K., Grzybowska, E., Klaes, R., Burwinkel, B., Bugert, P., Schmutzler, R.K., Wappenschmidt, B., Butkiewicz, D., Pamula, J., Pekala, W., Försti, A. Carcinogenesis (2006)
- Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells. Srikant, C.B., Shen, S.H. Endocrinology (1996)
- Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity. Garbrecht, N., Anlauf, M., Schmitt, A., Henopp, T., Sipos, B., Raffel, A., Eisenberger, C.F., Knoefel, W.T., Pavel, M., Fottner, C., Musholt, T.J., Rinke, A., Arnold, R., Berndt, U., Plöckinger, U., Wiedenmann, B., Moch, H., Heitz, P.U., Komminoth, P., Perren, A., Klöppel, G. Endocr. Relat. Cancer (2008)
- Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus. Goodyer, C.G., Grigorakis, S.I., Patel, Y.C., Kumar, U. Neuroscience (2004)
- Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease. Beal, M.F., Mazurek, M.F., Tran, V.T., Chattha, G., Bird, E.D., Martin, J.B. Science (1985)
- Effect of somatostatin infusion on the somatotrope responsiveness to growth hormone-releasing hormone in patients with anorexia nervosa. Gianotti, L., Rolla, M., Arvat, E., Belliti, D., Valetto, M.R., Ferdeghini, M., Ghigo, E., Müller, E.E. Biol. Psychiatry (1999)
- Somatostatin analogs in oncology: a look to the future. Jenkins, S.A., Kynaston, H.G., Davies, N.D., Baxter, J.N., Nott, D.M. Chemotherapy. (2001)
- Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Rocheville, M., Lange, D.C., Kumar, U., Patel, S.C., Patel, R.C., Patel, Y.C. Science (2000)
- Early administration of vapreotide for variceal bleeding in patients with cirrhosis. Calès, P., Masliah, C., Bernard, B., Garnier, P.P., Silvain, C., Szostak-Talbodec, N., Bronowicki, J.P., Ribard, D., Botta-Fridlund, D., Hillon, P., Besseghir, K., Lebrec, D. N. Engl. J. Med. (2001)
- Treatment of type II gastric carcinoid tumors with somatostatin analogues. Tomassetti, P., Migliori, M., Caletti, G.C., Fusaroli, P., Corinaldesi, R., Gullo, L. N. Engl. J. Med. (2000)
- Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. Virgolini, I., Raderer, M., Kurtaran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W., Valent, P. N. Engl. J. Med. (1994)
- Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. Gutniak, M., Orskov, C., Holst, J.J., Ahrén, B., Efendic, S. N. Engl. J. Med. (1992)
- Preserved insulin secretion and insulin independence in recipients of islet autografts. Pyzdrowski, K.L., Kendall, D.M., Halter, J.B., Nakhleh, R.E., Sutherland, D.E., Robertson, R.P. N. Engl. J. Med. (1992)
- The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2. Massa, A., Barbieri, F., Aiello, C., Iuliano, R., Arena, S., Pattarozzi, A., Corsaro, A., Villa, V., Fusco, A., Zona, G., Spaziante, R., Schettini, G., Florio, T. Ann. N. Y. Acad. Sci. (2004)
- Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndromes. Vinik, A.I., Tsai, S.T., Moattari, A.R., Cheung, P., Eckhauser, F.E., Cho, K. Am. J. Med. (1986)
- Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease. Pasquali, D., Notaro, A., Bonavolonta', G., Vassallo, P., Bellastella, A., Sinisi, A.A. J. Clin. Endocrinol. Metab. (2002)
- Expression of somatostatin receptor subtypes in cultured astrocytes and gliomas. Feindt, J., Becker, I., Blömer, U., Hugo, H.H., Mehdorn, H.M., Krisch, B., Mentlein, R. J. Neurochem. (1995)
- Cross-competition between vasoactive intestinal peptide and somatostatin for binding to tumor cell membrane receptors. Virgolini, I., Yang, Q., Li, S., Angelberger, P., Neuhold, N., Niederle, B., Scheithauer, W., Valent, P. Cancer Res. (1994)
- Regulation of acidification and apoptosis by SHP-1 and Bcl-2. Thangaraju, M., Sharma, K., Leber, B., Andrews, D.W., Shen, S.H., Srikant, C.B. J. Biol. Chem. (1999)
- Agonist-dependent up-regulation of human somatostatin receptor type 1 requires molecular signals in the cytoplasmic C-tail. Hukovic, N., Rocheville, M., Kumar, U., Sasi, R., Khare, S., Patel, Y.C. J. Biol. Chem. (1999)
- Somatostatin and its receptor family. Patel, Y.C. Frontiers in neuroendocrinology. (1999)
- Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors. Carlton, S.M., Du, J., Davidson, E., Zhou, S., Coggeshall, R.E. Pain (2001)
- Inhibitory effect of pasireotide and octreotide on lymphocyte activation. Lattuada, D., Casnici, C., Crotta, K., Mastrotto, C., Franco, P., Schmid, H.A., Marelli, O. J. Neuroimmunol. (2007)
- Somatostatin receptor gene expression and inhibitory effects of octreotide on primary cultures of orbital fibroblasts from Graves' ophthalmopathy. Pasquali, D., Vassallo, P., Esposito, D., Bonavolontà, G., Bellastella, A., Sinisi, A.A. J. Mol. Endocrinol. (2000)
- The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5. Wente, W., Efanov, A.M., Treinies, I., Zitzer, H., Gromada, J., Richter, D., Kreienkamp, H.J. FEBS Lett. (2005)
- Different response to the long-acting somatostatin analogues lanreotide and octreotide in a patient with a malignant carcinoid. Raderer, M., Kurtaran, A., Scheithauer, W., Fiebiger, W., Weinlaender, G., Oberhuber, G. Oncology (2001)
- The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing? Hejna, M., Schmidinger, M., Raderer, M. Ann. Oncol. (2002)
- Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. Shimon, I., Yan, X., Taylor, J.E., Weiss, M.H., Culler, M.D., Melmed, S. J. Clin. Invest. (1997)
- Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Yamada, Y., Reisine, T., Law, S.F., Ihara, Y., Kubota, A., Kagimoto, S., Seino, M., Seino, Y., Bell, G.I., Seino, S. Mol. Endocrinol. (1992)
- Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2. Ferrante, E., Pellegrini, C., Bondioni, S., Peverelli, E., Locatelli, M., Gelmini, P., Luciani, P., Peri, A., Mantovani, G., Bosari, S., Beck-Peccoz, P., Spada, A., Lania, A. Endocr. Relat. Cancer (2006)
- Cloning and characterization of a fourth human somatostatin receptor. Rohrer, L., Raulf, F., Bruns, C., Buettner, R., Hofstaedter, F., Schüle, R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. Lopez, F., Estève, J.P., Buscail, L., Delesque, N., Saint-Laurent, N., Théveniau, M., Nahmias, C., Vaysse, N., Susini, C. J. Biol. Chem. (1997)
- HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity. Yin, M.J., Gaynor, R.B. J. Mol. Biol. (1996)
- Colocalization of neuropeptides with calbindin D28k and NADPH diaphorase in the enteric nerve plexuses of normal human ileum. Dhatt, N., Buchan, A.M. Gastroenterology (1994)
- Presence and localization of CCK receptor subtypes in calf pancreas. Morisset, J., Lainé, J., Bourassa, J., Lessard, M., Rome, V., Guilloteau, P. Regul. Pept. (2003)
- Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease. Beal, M.F., Mazurek, M.F., Chattha, G.K., Svendsen, C.N., Bird, E.D., Martin, J.B. Ann. Neurol. (1986)
- Beta-arrestin is involved in the desensitization but not in the internalization of the somatostatin receptor 2A expressed in CHO cells. Brasselet, S., Guillen, S., Vincent, J.P., Mazella, J. FEBS Lett. (2002)
- Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5. Cordelier, P., Estève, J.P., Bousquet, C., Delesque, N., O'Carroll, A.M., Schally, A.V., Vaysse, N., Susini, C., Buscail, L. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Characterization of the somatostatin receptor subtype in a bronchial carcinoid tumor responsible for Cushing's syndrome. Lefebvre, H., Jégou, S., Leroux, P., Dero, M., Vaudry, H., Kuhn, J.M. J. Clin. Endocrinol. Metab. (1995)
- Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone. Veldhuis, J.D., Iranmanesh, A., Mielke, K., Miles, J.M., Carpenter, P.C., Bowers, C.Y. J. Clin. Endocrinol. Metab. (2006)
- Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans. Broglio, F., Koetsveld Pv, P., Benso, A., Gottero, C., Prodam, F., Papotti, M., Muccioli, G., Gauna, C., Hofland, L., Deghenghi, R., Arvat, E., Van Der Lely, A.J., Ghigo, E. J. Clin. Endocrinol. Metab. (2002)
- Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy. Lamberts, S.W., Hofland, L.J., de Herder, W.W., Kwekkeboom, D.J., Reubi, J.C., Krenning, E.P. Frontiers in neuroendocrinology. (1993)
- NIH conference. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Gorden, P., Comi, R.J., Maton, P.N., Go, V.L. Ann. Intern. Med. (1989)
- Localization of receptors for vasoactive intestinal peptide, somatostatin, and substance P in distinct compartments of human lymphoid organs. Reubi, J.C., Horisberger, U., Kappeler, A., Laissue, J.A. Blood (1998)
- Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. Mathern, G.W., Babb, T.L., Pretorius, J.K., Leite, J.P. J. Neurosci. (1995)
- A targeted cytotoxic somatostatin (SST) analogue, AN-238, inhibits the growth of H-69 small-cell lung carcinoma (SCLC) and H-157 non-SCLC in nude mice. Kiaris, H., Schally, A.V., Nagy, A., Szepeshazi, K., Hebert, F., Halmos, G. Eur. J. Cancer (2001)
- Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium. Ghosh, S., Choritz, L., Geibel, J., Coca-Prados, M. Mol. Cell. Endocrinol. (2006)