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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane.

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane ( DOM).[1]


  1. Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane. Jacob, P., Anderson, G., Meshul, C.K., Shulgin, A.T., Castagnoli, N. J. Med. Chem. (1977) [Pubmed]
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